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AssigneesHadasit Medical Research Services and Development Ltd., Ben-Gurion University of the Negev Research and Development Authority
InventorsYaron Ilan, Gadi Lalazar, Eyal Shteyer, Ami Ben-Yaakov, Smadar Cohen, Tsiona Elkayam
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The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.
A method for the treatment of hepatic disorders in a subject in need thereof, which method comprises the step of administering to said subject a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof.
A method for sustaining serum albumin levels in a subject suffering of hepatic disorder, wherein said method comprises the step of administering to said subject a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof.
A method for lowering the levels of any one of serum ALT and AST levels in a subject suffering of hepatic disorder, wherein said method comprises the step of administering to said subject a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof.
A method for reducing the level of apoptosis in a damaged liver tissue of a subject suffering of hepatic disorder, said method comprises the step of administering to said subject a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof.
A method for increasing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, said method comprises the step of administering to said subject a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof.
A biocompatible alginate biomaterial, any modification thereof and any combination thereof for use in the treatment of hepatic disorders.
18-33. (canceled)
Dependencies are inferred from the claim text.