Stabilized solubility-enhanced formulations for oral delivery
AssigneeAdds Pharmaceuticals LLC
InventorsLiang C. DONG, Katrina Andrea U. Co, Shu Li, Crystal Pollock-Dove
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Abstract
Methods and compositions are described whereby poorly water-soluble beneficial agents such as vitamins and co-factors are formulated into self-emulsifying formulas (SEF) and optionally sorbing the SEF into pores of porous solid particulates, or preparing supersaturated solutions (SSS) and sorbing the SSS into pores of porous solid particulates. These formulations are useful as dosage forms with oral availability.
Claims16
An oral dosage form comprising at least one poorly water-soluble beneficial agent, and a carrier which is:
- a) a self-emulsifying formulation (SEF) comprising a non-ionic water-miscible surfactant, a water-immiscible lipid-soluble component, and, optionally, a fatty acid mono- or di-glyceride;
- or
- b) an SEF as set forth in a) sorbed onto porous particulates;
- or
- c) a super-saturated solution (SSS) comprising an alcohol and a polymeric stabilizer sorbed onto porous particulates.
A drink concentrate comprising a SEF of at least one poorly water-soluble beneficial agent which agent is CoQ10, Vitamin A, Vitamin D, Vitamin E, or Vitamin K or mixtures thereof.
Dependencies are inferred from the claim text.