Orally Bioavailable Lipid-Based Constructs
AssigneeSDG, Inc.
InventorsW. Blair Geho, John R. Lau
Life of this patent
Estimating the term…
Abstract
The present invention is embodied by a composition capable inducing weight loss in a patient in need thereof.
Claims39
An orally bioavailable composition comprising gelatin and additional constituents, said constituents comprising a dynamically sized liposome, liposome fragment, and lipid particle, wherein said lipid particle comprises at least one lipid component and said liposome or liposome fragment comprises at least two lipid components, said composition further comprising at least one biotin-derived targeting agent, wherein said gelatin actively reversibly interacts with one or more of said constituents.
A method of making an orally bioavailable composition comprising gelatin and additional constituents, said constituents comprising a dynamically sized liposome, liposome fragment, and a lipid particle, wherein said liposome, liposome fragment, and lipid particle are generated from a mixture of lipid components, said composition further comprising at least one biotin-derived targeting agent, wherein said gelatin actively reversibly interacts with one or more of said constituents, said method comprising the steps of:
- mixing said lipid components and said at least one a biotin-derived targeting agent in aqueous media to form a mixture;
- adding said mixture to gelatin to form a gelatin-associated mixture;
- and
- drying said gelatin-associated mixture.
A method of affecting weight loss in a patient, said method comprising administering to said patient an effective amount of an orally bioavailable composition comprising gelatin and additional constituents, said constituents comprising a dynamically sized liposome, liposome fragment, and lipid particle, wherein said lipid particle comprises at least one lipid component and said liposome or liposome fragment comprises at least two lipid components, said composition further comprising at least one biotin-derived targeting agent, wherein said gelatin actively reversibly interacts with one or more of said constituents.
An orally bioavailable composition comprising gelatin and additional constituents, said constituents comprising a dynamically sized liposome, liposome fragment, and lipid particle, wherein said lipid particle comprises at least one lipid component and said liposome or liposome fragment comprises at least two lipid components, said composition further comprising D-biotin and, optionally, at least one biotin-derived or metal-derived targeting agent, wherein said gelatin actively reversibly interacts with one or more of said constituents.
A method of affecting weight loss in a patient, said method comprising administering biotin DHPE.
A method of affecting weight loss in a patient, said method comprising administering a composition comprising biotin DHPE.
A method of making an orally bioavailable composition comprising gelatin and additional constituents, said constituents comprising a dynamically sized liposome, liposome fragment, and a lipid particle, wherein said liposome, liposome fragment, and lipid particle are generated from a mixture of lipid components, said composition further comprising D-biotin, and optionally, at least one metal-derived or biotin-derived targeting agent, wherein said gelatin actively reversibly interacts with one or more of said constituents, said method comprising the steps of:
- mixing said lipid components and, optionally, said at least one metal-derived or biotin-derived targeting agent in aqueous media to form a mixture;
- adding D-biotin to said mixture to form a second mixture;
- adding said second mixture to gelatin to form a gelatin-associated mixture;
- and
- drying said gelatin-associated mixture.
A method of affecting weight loss in a patient, said method comprising administering to a patient an effective amount of a composition comprising gelatin and additional constituents, said constituents comprising a dynamically sized liposome, liposome fragment, and lipid particle, wherein said lipid particle comprises at least one lipid component and said liposome or liposome fragment comprises at least two lipid components, said composition further comprising D-biotin and, optionally, at least one biotin-derived or metal-derived targeting agent, wherein said gelatin actively reversibly interacts with one or more of said constituents.
A food additive, dietary supplement, or beverage additive comprising gelatin and additional constituents, said constituents comprising a dynamically sized liposome, liposome fragment, and lipid particle, wherein said lipid particle comprises at least one lipid component and said liposome or liposome fragment comprises at least two lipid components, said composition further comprising at least one biotin-derived targeting agent, wherein said gelatin actively reversibly interacts with one or more of said constituents.
A food additive, dietary supplement, or beverage additive comprising gelatin and additional constituents, said constituents comprising a dynamically sized liposome, liposome fragment, and lipid particle, wherein said lipid particle comprises at least one lipid component and said liposome or liposome fragment comprises at least two lipid components, said composition further comprising D-biotin and, optionally, at least one biotin-derived or metal-derived targeting agent, wherein said gelatin actively reversibly interacts with one or more of said constituents.
A method of maintaining the weight of a patient in need thereof, comprising administering a compound comprising An orally bioavailable composition comprising gelatin and additional constituents, said constituents comprising a dynamically sized liposome, liposome fragment, and lipid particle, wherein said lipid particle comprises at least one lipid component and said liposome or liposome fragment comprises at least two lipid components, said composition further comprising at least one biotin-derived targeting agent, wherein said gelatin actively reversibly interacts with one or more of said constituents.
A method of maintaining the weight of a patient in need thereof, comprising administering a compound comprising gelatin and additional constituents, said constituents comprising a dynamically sized liposome, liposome fragment, and lipid particle, wherein said lipid particle comprises at least one lipid component and said liposome or liposome fragment comprises at least two lipid components, said composition further comprising D-biotin and, optionally, at least one biotin-derived or metal-derived targeting agent, wherein said gelatin actively reversibly interacts with one or more of said constituents.
Dependencies are inferred from the claim text.