Pharmaceutical compositions comprising hgh for oral delivery
AssigneeNovartis AG
InventorsMoise Azria, Yatindra Joshi, Rosario Lobrutto, Linda Mindeholm, Ashish B. Patel
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Abstract
The present invention relates to dosage forms of human growth hormone, the use of an absorption enhancer to allow absorption of human growth hormone into the systemic circulation in a biologically active form, in particular after oral administration, as well as the use of oral dosage forms comprising human growth hormone and an absorption enhancer for the treatment of human growth hormone deficiencies and disorders associated therewith.
Claims31
A pharmaceutical composition comprising human growth hormone (hGH) and N(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), in a weight ratio of hGH to 5CNAC from 1:0.2 to 1:50, calculated on the basis of 5-CNAC in the free acid form.
20-25. (canceled)
Dependencies are inferred from the claim text.