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AssigneesIstituto Ortopedico Rizzoli, A.U.S.L. - Azienda Unita' Sanitaria Locale Di Cesena
InventorsDavide Melandri, Elena Bondioli, Roberto Giardino, Milena Fini
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A method of treatment of connective tissue includes the steps of providing a biological tissue or organ, coating the tissue or organ with an enzymatic solution capable of phagocytizing at least partly fibroblasts, macrophages, mast cells and other cells responsible for immune and rejection reactions in homologous and heterologous transplantations. The biological tissue or organ, after the treatment with the enzymatic solution is irradiated with ionizing electromagnetic radiations in order to obtain an acellular tissue which maintains its own extracellular matrix unchanged. Preferably, such radiations are gamma radiations having a frequency between 1019 and 1022 Hz, beta radiations or mixtures thereof.
A method of treatment of connective tissues or organs including the steps of providing a biological tissue or organ, coating the tissue or organ with an enzymatic solution capable of phagocytizing at least partly fibroblasts, macrophages, mast cells and other tissue-specific- or organ-specific cells responsible for immune and rejection reactions in homologous and heterologous transplantations, wherein such method further includes the steps of irradiating the tissue thus treated with ionizing radiations.
28-32. (canceled)
Dependencies are inferred from the claim text.