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US 2010/0247599 A1Published application
Drug-releasing polyelectrolyte coating, method for forming a drug-releasing polyelectrolyte coating, and implantable device
OwnerLutz Kröhne, Volker Fehring +1inventors
InventorsLutz Kröhne, Volker Fehring, Andreas Voigt
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Abstract
A drug-releasing polyelectrolyte coating includes: (a) at least two oppositely charged polyelectrolyte layers; (b) at least one pharmaceutical active drug which is covalently coupled to polyelectrolytes of at least one of the polyelectrolyte layers; (c) wherein the drug exhibits a release rate from the polyelectrolyte coating of less than 50% in 3 days.
Claims25
A drug-releasing polyelectrolyte coating, comprising:
- (a) at least two oppositely charged polyelectrolyte layers;
- (b) at least one pharmaceutical active drug which is covalently coupled to polyelectrolytes of at least one of the polyelectrolyte layers;
- (c) wherein the drug exhibits a release rate from the polyelectrolyte coating of less than 50% in 3 days.
A method for forming a drug-releasing polyelectrolyte coating, comprising the steps of:
- (a) providing a substrate comprising a surface;
- (a) depositing at least two oppositely charged polyelectrolyte layers on at least a portion of the surface to form a polyelectrolyte multilayer on the surface, at least one of the polyelectrolyte layers comprising at least one pharmaceutical active drug which is covalently coupled to polyelectrolytes of said at least one polyelectrolyte layer;
- (c) wherein the pharmaceutical active drug is coupled to the polyelectrolyte such that it exhibits a release rate from the polyelectrolyte layer of less than 50% in 3 days.
A method for forming a drug-releasing polyelectrolyte coating, comprising the steps of:
- (a) providing a substrate comprising a surface;
- (a) depositing at least two oppositely charged polyelectrolyte layers on at least a portion of the surface to form a polyelectrolyte multilayer on the surface, at least one of the polyelectrolyte layers comprising at least one pharmaceutical active drug which is covalently coupled to a polyelectrolyte of said at least one polyelectrolyte layer;
- (b) wherein the drug-coupled polyelectrolyte is deposited on the surface in a hypotonic solution.
Dependencies are inferred from the claim text.