Stabilization of Vaccines by Lyophilization
AssigneeSanofi Pasteur Biologics, LLC
InventorsDaniel C. Vellom, James E. Woiszwillo, Amy Woiszwillo, Dara O'Neil, Jennifer Woiszwillo, Cole Woiszwillo, Paul DeGeorge, Peter Ciarametaro
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Abstract
This invention provides pharmaceutical compositions, such as vaccines, and methods of making and using such compositions.
Claims43
A composition comprising a live, attenuated flavivirus one or more stabilizers, one or more bulking agents, and one or more buffer components.
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A composition comprising a protein or virus-based pharmaceutical product, human serum albumin, a glutamic acid alkali metal salt, one or more amino acids, and one or more sugars or sugar alcohols.
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A method of preparing a therapeutic composition, said method comprising subjecting
- a composition comprising a live, attenuated flavivirus, one or more stabilizers, one or more bulking agents, and one or more buffer components;
- or
- a composition comprising a protein or virus-based pharmaceutical product, human serum albumin, a glutamic acid alkali metal salt, one or more amino acids, and one or more sugars or sugar alcohols;
- to a freeze-drying process.
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A method of preventing or treating a disease or condition in a subject, the method comprising administering to the subject
- a composition comprising a live, attenuated flavivirus, one or more stabilizers, one or more bulking agents, and one or more buffer components;
- or
- a composition comprising a protein or virus-based pharmaceutical product, human serum albumin, a glutamic acid alkali metal salt, one or more amino acids, and one or more sugars or sugar alcohols.
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Dependencies are inferred from the claim text.