Chimeric sindbis-eastern equine encephalitis virus and uses thereof
OwnerIlya Frolov, Patricia V. Aguilar +2inventors
InventorsIlya Frolov, Patricia V. Aguilar, Scott C. Weaver, Slobodan Paessler
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Abstract
The present invention discloses a chimeric alphavirus comprising a Sindbis virus cDNA fragment and an Eastern equine encephalitis virus cDNA fragment. The present also discloses the use of this chimeric alphavirus as vaccines and in serological and diagnostic assays.
Claims22
An attenuated Eastern equine encephalitis virus comprising:
- a DNA encoding a chimeric Eastern equine encephalitis virus, said DNA comprising a Sindbis virus cDNA fragment and an Eastern equine encephalitis virus cDNA fragment comprising structural protein genes.
(canceled)
A vector comprising a DNA encoding a chimeric Eastern equine encephalitis virus, said DNA comprising a Sindbis virus cDNA fragment and a Eastern equine encephalitis virus cDNA fragment comprising structural protein genes.
(canceled)
The method of claim 15, wherein said individual is a human or a domestic animal.
Dependencies are inferred from the claim text.