Monoclonal antibodies against dengue and other viruses with deletion in fc region
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsAna P. Goncalvez, Robert H. Purcell, Ching-Juh Lai
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Abstract
The present invention relates to a variant of a parent polypeptide comprising an Fc region, which variant binds an Fc gamma receptor (FcγR) with lower affinity than the parent polypeptide and comprises a deletion of at least one amino acid in about position 100 to about position 150 in the Fc region and related nucleic acids, vectors, host cells and methods of producing the variant and methods for preventing or treating a disorder in a mammal.
Claims39
A composition comprising a peptide of SEQ ID NO:
- 51 or SEQ ID NO:
- 52, wherein said peptide comprises a deletion of at least 1 amino acid in about position 100 to about position 150.
A composition comprising a nucleic acid encoding a peptide of SEQ ID NO:
- 51 or SEQ ID NO:
- 52, wherein said peptide comprises a deletion of at least 1 amino acid in about position 100 to about position 150.
Dependencies are inferred from the claim text.