Modulation of the th-17 cell mediated immune responses
OwnerChen Dong, Roza Nurievainventors
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Abstract
Methods of treating diseases or conditions associated with TH 17 cell mediated immune response are provided where a subject is administered an effective amount of an agent that modulates the IL-21 signaling pathway so as to inhibit or induce the differentiation of TH17 cells and/or the expression of IL-17, IL17-F, IL-22, and IL-21.
Claims5
A method of treating a disease or condition associated with TH17 cell mediated immune response in a subject in need thereof comprising the step of administering to the subject a therapeutically effective amount of an agent that modulates the IL-21 signaling pathway in an amount effective to modulate the differentiation of TH17 cells or the expression of IL-17, IL17-F, IL-22, and IL-21.
A method of treating an inflammatory disease or condition in a subject in need thereof comprising the step of administering to the subject a therapeutically effective amount of an agent that modulates the IL-21 signaling pathway so as to modulate the differentiation of TH17 cells.
A method of modulating the differentiation of TH17 cells comprising the steps of modulating the IL-21 signaling pathway and the expression of IL-17, IL17-F, IL-22, or IL-21 by TH17 cells whereby the generation of TH17 cells is induced or inhibited and an immune response modified.
Dependencies are inferred from the claim text.