Fused heterocyclic compounds as inhibitors of potassium channel function

A compound of formula I

• wherein,
• n and m are integers such that ring H, including atoms shared with its fusion partner ring G, is a 5 to 7 membered ring;
• A, B, D and E are independently —CR6═, —CR6—, —C(═O)—, —N═, —O—, —S—, a single bond, or a double bond, such that ring G, including atoms shared with its fusion partner ring H, is a 5 to 6 membered heterocycle wherein at least one ring atom is nitrogen, and ring G and —C(═O)—, if present, contains at least one unsaturated bond;
• R1 is aryl, which ring can be substituted with one or more groups of the formula —(CH2)p—(Z1)q—(CH2)r—Z2;
• R2 is aryl, heteroaryl, cycloalkyl or heterocyclo, which ring structures can each be substituted with one or more groups of the formula —(CH2)p—(Z1)q—(CH2)r—Z2, which substituents may, in one or more pairs of two, together with the atoms to which they are bonded, form a carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic group;
• Y is —C(═O)—, —C(═S)—, —C(═NR9)—, —C(═NR19)NR11—, —C(═O)—O—, —C(═S)—O—, —C(═NR12)—O—, —SO2—, —SO2—O—, or a single bond;
• R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are the same or different and are each independently selected from a group of formula —(CH2)p-(Z′)q—(CH2)rZ2;
• or R3, R4 and R5 may, in one or more pairs of two selected from R5 and R3, R2 and R3, R3 and R4 and R4 and R5, together with the atoms to which they are bonded, form a carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic group;
• or
• R6 and R7 may, in one or more pairs of two, together with the atoms to which they are bonded, form a carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic group;
• or
• two occurrences of R6 and R6* may, together with the atoms to which they are bonded, form a phenyl, which may be substituted;
• Z1 is —CZ3Z4—, —O—, —NZ5—, —S—, —SO—, —SO2—, —C(O)Z6—, —C(O)NZ7—, —C(S)—, —C(═NOZ8)—, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo;
• Z2 is hydrogen, —OZ9, —OC(O)Z10, —NZ13—C(O)-Z12, —NZ13—CO2-Z14, —NZ15(C═O)—NZ16Z17, —NZ18Z19, —NO2, halo, —CN, —C(O)Z20, —CO2Z21, —C(S)Z22, —(C═NOZ23)Z24, —C(O)NZ25Z26, C(S)NZ27Z28, —SZ29, —SOZ30, —SO2Z31, —SO2NZ32Z33, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo, or Z2 together with Z5 may together with a nitrogen to which they are bonded, form a carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic group;
• Z5 is hydrogen, —C(O)Z20, —CO2Z21, —C(S)Z22, —(C═NOZ23)Z24, —C(O)NZ25Z26, —C(S)NZ27Z28, —SZ29, —SOZ30, —SO2Z31, —SO2NZ32Z33, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo or Z5 forms a ring with Z2 as specified above;
• Z3, Z4, Z6, Z7, Z8, Z9, Z10, Z11, Z12, Z13, Z14, Z15, Z16, Z17, Z18, Z19, Z20, Z21, Z22, Z23, Z24, Z25, Z26, Z27, Z28, Z29, Z30, Z31, Z32 and Z33 are each independently hydrogen, halo, alkyl, substituted alkyl, alkenyl;
• substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo;
• or
• Z3, Z4, Z6, Z7, Z8, Z9, Z10, Z11, Z12, Z13, Z14, Z15, Z16, Z17, Z18, Z19, Z20, Z21, Z22, Z23, Z24, Z25, Z26, Z27, Z28, Z29, Z30, Z31, Z32 and Z33 may, in one or more pairs of two, together with the atoms to which they are bonded, form a carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic group;
• p and r are each independently selected from integers from 0 to 10;
• and
• q is an integer selected from 0 or 1, wherein, when q is 0, r is also 0;
• and salts of the foregoing;
• excluding the following compounds:
• N-(2-Amino-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-2-methoxy-benzamide;
• 2-Methoxy-N-(2-methyl-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-benzamide;
• N-(2-tert-Butyl-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-2-methoxy-benzamide;
• 2-Methoxy-N-(2-methylsulfanyl-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-benzamide;
• 2-Methoxy-N-(2-methoxy-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-benzamide;
• 2-Methoxy-N-(6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-benzamide;
• N-(2-Dimethylamino-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-2-methoxy-benzamide (enantiomer 1);
• N-(2-Dimethylamino-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-2-methoxy-benzamide (enantiomer 2);
• 2-Methoxy-N-(2-methylamino-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-benzamide (enantiomer 1);
• 2-Methoxy-N-(2-methylamino-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-benzamide (enantiomer 2);
• N-(2-Ethylamino-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-2-methoxy-benzamide (enantiomer 1);
• N-(2-Ethylamino-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-2-methoxy-benzamide (enantiomer 2);
• 2-Methoxy-N-(2-morpholin-4-yl-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-benzamide (enantiomer 1);
• 2-Methoxy-N-(2-morpholin-4-yl-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-benzamide (enantiomer 2);
• N-(2-Dimethylamino-4-methyl-6-phenyl-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-2-methoxy-benzamide;
• and
• N-(2-Dimethylamino-4-oxo-6-phenyl-3,4,5,6,7,8-hexahydro-quinazolin-6-ylmethyl)-2-methoxy-benzamide.