Humanized anti-venezuelan equine encephalitis virus recombinant antibodies
AssigneeHer Majesty the Queen in Right of Canada as Repres
InventorsWei-Gang Hu, Leslie P. Nagata
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Abstract
A CDR grafted humanized recombinant antibody against infection from Venezuelan equine encephalitis virus (VEEV) comprises a human Ig framework having CDRs from murine mAb 1A4A1 VH and VL. DNA sequences, expression vectors incorporating such sequences and transformed host cells are also provided. Also provided are pharmaceutical compositions and methods of prophylaxis and treatment against VEEV infection using the humanized recombinant antibodies of the invention.
Claims23
A use of a humanized recombinant antibody in the prophylaxis or treatment against infection from Venezuelan equine encephalitis virus, VEEV, in a mammal, wherein said antibody comprises a human Ig framework and having grafted thereon complementarity determining regions, CDRs, from the murine monoclonal antibody 1A4A1.
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A method of preventing or treating VEEV infection in a mammal comprising administering to said mammal a humanized recombinant antibody comprises a human Ig framework and having grafted thereon complementarity determining regions, CDRs, from the murine monoclonal antibody 1A4A1.
Dependencies are inferred from the claim text.