Arrays, kits and cancer characterization methods
OwnerKent Hunter, Nigel Crawfordinventors
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Abstract
The invention provides an array comprising a substrate and a set of addressable elements, wherein each addressable element comprises (i) a polynucleotide that specifically binds to a target molecule, (ii) a polypeptide that specifically binds to target molecule, or (iii) a combination of (i) and (ii), wherein the target molecule is selected from the group of cancer-related target molecules as defined herein. Related kits, methods, and uses as described herein are further provided by the invention.
Claims29
An array comprising a substrate and a set of addressable elements, wherein each addressable element comprises (i) a polynucleotide that specifically binds to a target molecule, (ii) a polypeptide that specifically binds to a target molecule, or (iii) a combination of (i) and (ii), wherein the target molecule is selected from the group consisting of the target molecules listed in Table 1, wherein the array comprises less than 38,500 addressable elements, wherein, when the array is specific for the target molecules in Table 3, the array is specific for at least one target molecule listed in Table 1 that is not listed in Table 3.
An array comprising a substrate and a set of addressable elements, wherein each addressable element comprises (i) a polynucleotide that specifically binds to a target molecule, (ii) a polypeptide that specifically binds to a target molecule, or (iii) a combination of (i) and (ii), wherein the target molecule is selected from the group consisting of the target molecules listed in Table 2, wherein the array comprises less than 38,500 addressable elements, wherein, when the array is specific for the target molecules in Table 3, the array is specific for at least one target molecule listed in Table 2 that is not listed in Table 3.
A kit comprising a set of user instructions and (i) a set of polynucleotides, (ii) a set of polypeptides, or (iii) a combination of (i) and (ii), wherein the set of polynucleotides is specific for one or more of the target molecules listed in Table 1, wherein the set of polypeptides is specific for one or more of the target molecules listed in Table 1, wherein the kit is specific for less than 38,500 target molecules, wherein, when the kit is specific for the target molecules in Table 3, the kit is specific for at least one target molecule listed in Table 1 that is not listed in Table 3.
A kit comprising a set of user instructions and (i) a set of polynucleotides, (ii) a set of polypeptides, or (iii) a combination thereof, wherein the set of polynucleotides is specific for one or more of the target molecules listed in any of Table 2, wherein the set of polypeptides is specific for one or more of the target molecules listed in any of Table 2, wherein the kit is specific for less than 38,500 target molecules, wherein, when the kit is specific for the target molecules in Table 3, the kit is specific for at least one target molecule listed in Table 2 that is not listed in Table 3.
A method of characterizing a tumor or cancer in a subject comprising (i) detecting the expression levels of a set of target molecules in the subject, wherein the set of target molecules consists of all the target molecules listed in Table 1 or 2, or any of Groups 1 to 9, or a combination thereof, and (ii) comparing the expression levels of the set of target molecules to a control set of expression levels.
26-27. (canceled)
Dependencies are inferred from the claim text.