Compositions comprising semaphorins for the treatment of angiogenesis related diseases and methods of selection thereof
AssigneeRappaport Family Institute for Research Research in the Medical Sciences
InventorsGera Neufeld, Boaz Kigel, Ofra Kessler, Asya Varshavsky
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Abstract
A method of selecting a semaphorin for treating cancer in a subject is disclosed. The method comprises determining an expression of a semaphorin receptor on tumor cells of a tumor sample of the subject wherein an amount of the semaphorin receptor is indicative of the semaphorin suitable for treating the cancer in the subject. Methods of treating angiogenesis, kits for treating cancer and pharmaceutical compositions comprising semaphorins are also disclosed.
Claims19
A method of selecting a semaphorin for treating cancer in a subject, said semaphorin being selected from the group consisting of Sema3D, Sema3E and Sema 3G, the method comprising determining an expression of a semaphorin receptor on cells of a tumor sample of said subject wherein an amount of said semaphorin receptor is indicative of the semaphorin suitable for treating the cancer in the subject.
A kit for treating cancer, the kit comprising at least one agent capable of identifying a semaphorin receptor sub-type and at least one semaphorin, said semaphorin being selected from the group consisting of Sema3D, Sema3E and Sema 3G.
9-10. (canceled)
(canceled)
A method of treating a disease associated with angiogenesis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a semaphorin selected from the group consisting of Sema3D, Sema3E and Sema3G, thereby treating the disease associated with angiogenesis.
(canceled)
A pharmaceutical composition comprising as an active ingredient a semaphorin selected from the group consisting of Sema3D, Sema3E and Sema 3G and a pharmaceutically acceptable currier.
Dependencies are inferred from the claim text.