Compositions of Mesenchymal Stem Cells to Regenerate Bone
AssigneeThe Texas A&M University System
InventorsCarl A. Gregory, Darwin J. Prockop
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Abstract
The present invention encompasses an osteogenic composition comprising mesenchymal stem cells pre-cultured in the presence of an agent that accelerates canonical Wnt signaling therein. Also, provided are osteogenic compositions incorporated into a biocompatible gel. The present invention provides methods for treating bone degeneration or injury associated with a pathophysiological condition in a mammal or for accelerating repair of a skeletal injury in a mammal by administering to the mammal or contacting the site of injury with the osteogenic composition.
Claims23
A composition comprising a mesenchymal stem cell (MSC) pre-cultured in the presence of an agent that activates canonical Wnt signaling therein.
A composition comprising a mesenchymal stem cell (MSC) and an agent that activates canonical Wnt signaling therein.
A method of treating bone degeneration or injury associated with a pathophysiological condition in a mammal, the method comprising:
- administering to the mammal in need thereof an effective amount of a composition comprising a mesenchymal stem cell (MSC) pre-cultured in the presence of an agent that activates canonical Wnt signaling therein, thereby treating the bone degeneration or injury in said mammal.
A method of accelerating repair of a skeletal injury in a mammal, the method comprising:
- directly contacting the site of the skeletal injury with an effective amount of a composition comprising a mesenchymal stem cell (MSC) pre-cultured in the presence of an agent that activates canonical Wnt signaling therein thereby accelerating bone repair.
A mesenchymal stem cell (MSC) pre-cultured in the presence of an agent that activates canonical Wnt signaling therein, wherein said MSC exhibits an elevated osteogenic characteristic compared to an otherwise identical MSC not pre-cultured in the presence of said agent.
An MSC-derived lattice comprising extracelluar matrix secreted from an MSC pre-cultured in the presence of an agent that activates canonical Wnt signaling therein that has been induced to differentiate to exhibit at least one characteristic of a bone cell.
Dependencies are inferred from the claim text.