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US 2010/0247491 A1Published application
Potentiation of Stem Cell Homing and Treatment of Organ Dysfunction or Organ Failure
OwnerChristof Westenfelderinventor
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Abstract
The invention provides methods and compositions for the treatment of multi-organ failure or kidney dysfunction, such as acute renal failure, by mesenchymal stem cells and a CD26 inhibitor, where inhibition of CD26 increases homing of the mesenchymal stem cells to a target tissue.
Claims20
A method of treating multi-organ failure, acute renal failure, chronic renal failure, or kidney dysfunction in a subject, the method comprising:
- administering a therapeutically effective amount of a CD26 inhibitor to a subject;
- and
- co-administering a therapeutically effective amount of mesenchymal stem cells to the subject.
A method of treating multi-organ failure, acute renal failure, chronic renal failure, or kidney dysfunction in a subject, the method comprising:
- treating mesenchymal stem cells in vitro with an effective amount of a CD26 inhibitor;
- and
- administering a therapeutically effective amount of the CD26 treated mesenchymal stem cells to a subject.
-24. (canceled)
Dependencies are inferred from the claim text.