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US 2010/0247487 A1Published application
In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
AssigneeBiovec, LLC
InventorsLakshman R. SEHGAL, Jonathan Wong
Life of this patent
Estimating the term…
Abstract
A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.
Claims15
1-20. (canceled)
A method for improving allograft survival, comprising:
- perfusing a kidney harvested from an organ donor with an effective amount of a gutless adenovirus carrying a nucleotide sequence encoding an immune modulator and a regulatory element operably linked to said nucleotide sequence;
- and
- transplanting the perfused kidney into a subject in need of a kidney transplant,
- wherein said gutless adenovirus expresses said immune modulator in said kidney.
1 more element
31-41. (canceled)
Dependencies are inferred from the claim text.