Combination therapy of an afucosylated antibody and one or more of the cytokines gm csf, m csf and/or il3
OwnerHeinrich Barchet, Georg Fertig +1inventors
InventorsHEINRICH BARCHET, GEORG FERTIG, CLAUDIA KIRSTENPFAD
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Abstract
The present invention is directed to the combination therapy of an afucosylated antibody specifically binding to a tumor-antigen with one or more cytokines selected from the group of human GM-CSF, human M-CSF and/or human IL-3 for the treatment of cancer.
Claims16
A method for the treatment of cancer, comprising administering to a patient in need of such treatment (i) an afucosylated antibody with an amount of fucose is 60% or less;
- and (ii) one or more cytokines selected from the group consisting of human GM-CSF, human M-CSF and human IL-3.
A composition comprising an afucosylated antibody specifically binding to a tumor antigen with an amount of fucose of 60% or less and one or more cytokines selected from the group consisting of human GM-CSF, human M-CSF and human IL-3.
Dependencies are inferred from the claim text.