Tight junction modulator peptides for enhanced mucosal delivery of therapeutic compounds
AssigneeNastech Pharmaceutical Company Inc.
InventorsKunyuan Cui, Shu-Chih Chen, Michael E. Houston, JR., Steven C. Quay
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Abstract
Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian subject, in which the permeabilizing peptide is a PN159 analog or conjugate.
Claims21
An isolated peptide comprising a sequence selected from the group consisting of SEQ ID NOs:1 and 20-23 lengthened by one or more amino acid residues, and pharmaceutically-acceptable salts thereof.
An isolated peptide comprising a sequence selected from the group consisting of
- SEQ ID NOs:1 and 20-23, and variants thereof, having 14-26 amino acid residues, wherein the peptide has at least two D-amino acid residues, and pharmaceutically-acceptable salts thereof.
An isolated peptide comprising the retro-inverso of a sequence selected from the group consisting of SEQ ID NOs:1 and 20-23, and variants thereof, having 14-26 amino acid residues, and pharmaceutically-acceptable salts thereof.
An isolated peptide comprising a sequence selected from the group consisting of
- SEQ ID NOs:1 and 20-23, and variants thereof, having 14-26 amino acid residues, wherein the peptide is enriched with at least 60% lysine, leucine, and/or alanine, and pharmaceutically-acceptable salts thereof.
Dependencies are inferred from the claim text.