Phenoxy-pyrrolidine derivative and its use and compositions

The compound (R)-2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone.

The compound 2-(4-hydroxymethyl)phenoxy)-1-(3-(2-trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone.

A pharmaceutical composition comprising:

• the compound (S)-2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, or a pharmaceutically acceptable salt of said compound;
• and a pharmaceutically acceptable carrier, vehicle, diluent or excipient.

A pharmaceutical composition comprising:

• the compound (S)-2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, or a pharmaceutically acceptable salt of said compound;
• a second therapeutic agent;
• and a pharmaceutically acceptable carrier, vehicle, diluent or excipient.

A method of treating or alleviating a condition associated with excess sebum production in a mammal, including a human, in need of such treatment comprising administering to said mammal a therapeutically effective amount of (S)-2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, or a pharmaceutically acceptable salt of said compound, alone or in combination with a second therapeutic agent.

A method of treating or alleviating a condition selected from acne, oily skin, oily hair, shiny skin, greasy-looking skin, greasy-looking hair, or seborrheic dermatitis in a mammal, including a human, in need of such treatment comprising administering to said mammal a therapeutically effective amount of (S)-2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, or a pharmaceutically acceptable salt of said compound, alone or in combination with a second therapeutic agent.

A method of inhibiting the activity of stearoyl CoA desaturase in a mammal, including a human, in need of such treatment comprising administering to said mammal a therapeutically effective amount of (S)-2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, or a pharmaceutically acceptable salt of said compound, alone or in combination with a second therapeutic agent.