Drug delivery system for hydrophobic drugs
AssigneeValeant Pharmaceuticals International
InventorsRonald Erwin Boch, Dev Mitra Ranji Singh, Iman Karmadi
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Abstract
Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favoring the production of small aggregates for improved filter sterilization.
Claims39
A lyophilized composition containing saturated and unsaturated phospholipids and one or more photosensitizer,
- wherein the composition, upon rehydration, produces micelles with an average diameter below about 100 nm.
A lyophilized composition,
- containing saturated and unsaturated phospholipids and
- one or more photosensitizer;
- wherein the composition, upon rehydration, produces micelles with an average diameter below 100 nm;
- and wherein the unsaturated phospholipid is egg phosphatidylglycerol (EPG).
A method for making a lyophilized composition containing one or more photosensitizers and a mixture of saturated and unsaturated phospholipids, wherein said method comprises the steps of:
- producing a mixture of an organic solvent, photosensitizers and phospholipids capable of forming a lipid bilayer to form an “intermediate complex”;
- removing said solvent to produce a “presome” material;
- hydrating said “presome” material with an aqueous solvent;
- and
- processing by high energy manipulation said hydrated material to produce a composition containing micelles;
- and
- lyophilizing said composition to produce a lyophilized composition, wherein said composition, upon rehydration, produces micelles.
Dependencies are inferred from the claim text.