Polymeric drug carrier for image-guided delivery
AssigneeKoninklijke Philips Electronics N.V.
InventorsSander Langereis, Holger Gruell, Lea Louise Pauline Messager, Jeroen Alphons Pikkemaat, Dirk Burdinski
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Abstract
Described are Chemical Exchange-dependent Saturation Transfer (CEST) contrast agents for Magnetic Resonance Imaging (MRI) comprising a polymersome provided with a paramagnetic agent. The polymersome preferably comprises a polymeric shell enclosing a cavity, wherein the cavity comprises a pool of proton analytes, and wherein the shell allows diffusion of the proton analytes. The polymersome-based CEST MRI contrast agents are suitable as drug carriers useful in MRI-guided drug release.
Claims15
A Chemical Exchange-dependent Saturation Transfer (CEST) contrast agent for Magnetic Resonance Imaging (MRI) comprising a polymersome provided with a paramagnetic agent.
Dependencies are inferred from the claim text.