Loading patent…
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsFrank L. Greenway, Zhijun Liu, Eugene A. Woltering
Estimating the term…
An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.
A method of ameliorating or preventing angiogenesis in a mammal, said method comprising administering to the mammal a therapeutically effective amount of gallic acid or its derivatives.
A method of decreasing the size of an existing capillary network in a mammal, wherein the growth and maintenance of the network depends on angiogenesis, said method comprising administering to the mammal a therapeutically effective amount of gallic acid or its derivatives.
A method of ameliorating or preventing angiogenesis in a mammal, said method comprising administering to the mammal a therapeutically effective amount of an active plant extract.
A method of decreasing the size of an existing capillary network in a mammal, wherein the growth and maintenance of the network depends on angiogenesis, said method comprising administering to the mammal a therapeutically effective amount of an active plant extract.
An anti-angiogenic composition, wherein said composition is more soluble in alcohol than in water;
An anti-angiogenic composition, wherein said composition is more soluble in alcohol than in water;
An anti-angiogenic composition, wherein said composition is more soluble in alcohol than in water;
The method of claim 103, wherein the administration is by subcutaneous injection into the fat tissue.
An anti-angiogenic composition, wherein said composition is more soluble in alcohol than in water;
Dependencies are inferred from the claim text.