Methods and Compositions for Modulating T Cells
OwnerAndrew Chan, Jung-Hua Yehinventors
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Abstract
The invention provides methods and compositions useful for modulating T cells, and disorders associated with the dysregulation thereof.
Claims83
A method for the treatment of an autoimmune disease, comprising administering to a subject an effective amount of a CRTAM modulator, wherein said modulator inhibits CRTAM activity in an activated T cell subpopulation, whereby the disease is treated.
The method of 13, wherein said T cells are autoreactive.
A method of treating a disorder comprising administering to a subject an effective amount of a CRTAM modulator that enhances CD4+ T cell activity, wherein said disorder is a cancer, an immune deficiency, or an infection.
A method of inhibiting a biological activity associated with T cell activation comprising contacting a CRTAM modulator with a T cell, wherein said modulator inhibits activity of a CRTAM-expressing T cell.
A method of enhancing a biological activity associated with T cell activation comprising contacting a CRTAM modulator with a CD4+ T cell, wherein said modulator enhances activity of a CRTAM-expressing CD4+ T cell.
A method for detecting an autoimmune disease comprising:
- (a) contacting a CRTAM modulator with a first test sample comprising T cells from a subject and a control;
- and
- (b) determining that a relative amount of CRTAM+ cells in said test sample is higher than a relative amount of CRTAM+ cells in said control, wherein said higher relative amount of CRTAM+ cells in said test sample is indicative of an autoimmune disease in said mammalian subject.
An isolated population of activated CD4+ T cells characterized by (1) expression of CRTAM;
- and (2) an elevated expression level of one or more cytokines relative to CD4+ activated T cells not expressing CRTAM.
A method for isolating a population of activated CD4+ T cells, comprising contacting a sample comprising a mixed population of T cells from a subject with an anti-CRTAM antibody and separating any cells from said mixed population that do not bind said CRTAM antibody, wherein a population of activated CD4+ T cells bound by said CRTAM antibody remains in said sample.
A kit comprising a CRTAM modulator and instructions for administering said modulator to treat an autoimmune disease.
Use of a CRTAM modulator in the preparation of a medicament to treat an autoimmune disease.
A CRTAM modulator for use in the treatment of an autoimmune disease.
Dependencies are inferred from the claim text.