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US 2010/0240883 A1Published application
Lipid-drug conjugates for drug delivery
OwnerNian Wu, Brian Charles Kellerinventors
Life of this patent
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Abstract
New prodrugs are derived from highly water soluble parent drugs that exist as primary or secondary amines in their parent form. Lipophilic carrier groups are bonded to the parent drug via an amide linkage with additional linker elements between the amide group and the carrier group.
Claims7
A prodrug of a parent drug having either a primary or secondary amine, the prodrug represented by the formula:
- where R is a diacyl carrier group, N(H)-D represents the parent drug portion of the prodrug and Z is selected from the group consisting of —CH3, —CH2SH, —H, —CH2-imidazole, —CH(CH3)CH2CH3, —CH2CH(CH3)2, —CH2CH2CH2CH2NH2, —CH2CH2SCH3, —CH2C6H5, —CH2OH, —CH(OH)CH3, —CH2-indole, —CH2-hydroxyphenyl, and —CH(CH3)2.
Dependencies are inferred from the claim text.