Recombinant Rhinovirus Vectors
AssigneeSanofi Pasteur Biologics, LLC
InventorsKirill Kalnin, Yanhua Yan, Harold Kleanthous
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Abstract
The invention provides recombinant rhinovirus vectors including, for example, influenza virus antigens. Also provided by the invention are corresponding pharmaceutical compositions and methods.
Claims31
A rhinovirus vector comprising an influenza virus antigen.
A NimII peptide comprising an inserted influenza antigen.
A method of generating a rhinovirus vector comprising an influenza virus antigen, the method comprising the steps of:
- (i) generating a library of recombinant rhinovirus vectors based on an infectious cDNA clone that comprises inserted influenza virus antigen sequences, and
- (ii) selecting from the library recombinant viruses that (a) maintain inserted sequences upon passage, and (b) are neutralized with antibodies against the inserted sequence.
A method of cultivating a rhinovirus vector comprising an influenza virus antigen, the method comprising passaging the vector in HeLa or MRC-5 cells.
A rhinovirus vector comprising a pathogen, cancer, or allergen-based antigen, as described herein.
Dependencies are inferred from the claim text.