Kaspp (lrrk2) gene, its production and use for the detection and treatment of neurodegenerative disorders

An isolated nucleic acid molecule comprising a polynucleotide sequence selected from:

• (a) nucleotides 1 to 9104 of SEQ ID NO:
• 1 or 2;
• (b) nucleotides 1 to 7584 of SEQ ID NO:
• 1 or 2;
• (c) nucleotides 1 to 7581 of SEQ ID NO:
• 1 or 2;
• (d) a nucleotide sequence coding for the protein sequence of SEQ ID NO:
• 1 or 2 or for the protein sequence of SEQ ID NO:
• 1 or 2 containing at least one of the mutations depicted in SEQ ID NO:
• 1 or 2;
• (e) a nucleotide sequence complementary to either of the nucleotide sequences in (a), (b), (c) or (d);
• and/or
• (f) a nucleotide sequence which hybridizes under high stringency conditions to any of the nucleotide sequences in (a), (b), (c), (d) or (e) and which codes for the protein sequence of SEQ ID NO:
• 1 or 2 or for the protein sequence of SEQ ID NO:
• 1 or 2 containing at least one of the mutations depicted in SEQ ID NO:
• 1 or 2.