Natural biodegradable matrices and uses thereof
AssigneeSurModics, Inc.
InventorsStephen J. Chudzik, Joseph A. Chinn, Dale G. Swan, Michael J. Burkstrand
Life of this patent
Estimating the term…
Abstract
Matrices formed from a natural biodegradable material and that exhibit surface degradation in the presence of an enzyme are described. Matrices including a bioactive agent can be implanted or formed in a subject for release of the bioactive agent upon degradation of the matrix. The matrix can be provided in various forms, including coatings for implantable devices, implants, and in-situ formed matrices. The matrix can also be in the form of a medical device having a structure that is used to treat a medical condition.
Claims21
A method of delivering a bioactive agent to a subject comprising the steps of:
- providing a matrix of natural biodegradable material comprising bioactive agent entrapped within the matrix, wherein the matrix has a surface, and wherein the matrix is implanted or immobilized within the subject;
- and
- allowing the surface to be contacted with an enzyme, wherein the matrix prevents the enzyme from entering the matrix, wherein the enzyme degrades the matrix at the surface, and wherein bioactive agent is released from the matrix upon degradation of the natural biodegradable material.
15-20. (canceled)
Dependencies are inferred from the claim text.