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US 2010/0226940 A1Published application
Herpes simplex virus mutant icp0
AssigneesUniversity of Kansas, Southern Illinois University
InventorsDavid Davido, William Halford
Life of this patent
Estimating the term…
Abstract
A mutant herpesvirus that has a mutated gene that encodes a mutant infected cell protein 0 (ICP0) can be used in therapeutic methods as well as in diagnostics and research experiments. The encoded mutant ICP0 protein can be altered in one or more regions of ICP0 that are substantially conserved between two or more herpesviruses and/or within a phosphorylation region. The mutant herpesvirus can be substantially avirulent and immunogenic.
Claims27
A mutant herpesvirus comprising:
- a mutated gene that encodes:
- a mutant infected cell protein 0 (ICP0) that is altered in one or more regions of ICP0 that are substantially conserved between two or more herpesviruses, wherein the mutant herpesvirus is substantially avirulent and immunogenic.
An immunogenic composition comprising:
- a pharmaceutically acceptable carrier;
- and
- a mutant herpesvirus gene that encodes:
- a mutant infected cell protein 0 (ICP0) that is altered in one or more regions of ICP0 that are substantially conserved between two or more alpha-herpesviruses, wherein the mutant herpesvirus is substantially avirulent and immunogenic.
1 more element
A method of immunizing a subject, the method comprising:
- administering to the subject an immunogenic composition having a mutant herpesvirus gene that encodes:
- a mutant infected cell protein 0 (ICP0) that is altered in one or more regions of ICP0 that are substantially conserved between two or more herpesviruses, wherein the mutant herpesvirus is substantially avirulent and immunogenic.
Dependencies are inferred from the claim text.