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US 2010/0221255 A1Published application
Apelin peptides and methods of use
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human, Services
InventorsFrank Cuttitta, Ingalill Avis, David Salomon
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Abstract
The present disclosure concerns the use of biologically active apelin peptides and compositions that are processed from larger precursor proteins and further post-translationally modified to influence cell growth. Particular methods are useful for promoting cell growth, while others are particularly useful for inhibiting cell growth.
Claims26
An isolated polypeptide, consisting of an amino acid sequence selected from the group consisting of:
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- 43, wherein the amino acid sequence has up to four amino acid substitutions, which substitutions are not at the last position of the amino acid sequence, and has cell growth modulating activity.
19 more elements
Dependencies are inferred from the claim text.