Back to results
US 2010/0217020 A1Published application
Process for producing vitamin d derivative using convergent method
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsKunio Ogasawara, Takashi Emura, Akira Kawase, Koji Takano, Keisuke Yamamoto, Yoshiaki Kato
Life of this patent
Estimating the term…
Abstract
There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(19),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide, which process is shown in the following reaction scheme: an intermediate useful for carrying out the process, and a process for producing the intermediate.
Claims13
A process for producing a compound represented by Formula (1):
- said process comprising the step of reacting a compound represented by Formula (2):
- (wherein X represents a halogen atom)
- with a compound represented by Formula (3):
- (wherein R1 and R2, which may be the same or different, each represent a hydrogen atom or a protective group)
- in the presence of a palladium catalyst to produce a compound represented by Formula (4):
- (wherein R1 and R2 are as defined above).
3 more elements
A compound represented by Formula (2):
- (wherein X represents a halogen atom).
A compound represented by Formula (5):
- (wherein X represents a halogen atom).
A process for producing a compound:
- comprising the steps of:
- reacting bromomethyltriphenylphosphonium bromide with a base to produce a phosphorus ylide;
- and
- reacting said phosphorus ylide with a compound:
- to produce the desired compound.
2 more elements
Dependencies are inferred from the claim text.