US 2010/0215641 A1 · SCREENING METHOD FOR COMPOUNDS THAT REDUCE ER STRESS

Screening method for compounds that reduce er stress

AssigneeBioalvo-Servicos, Investigacao e Desenvolvirmento em Biotecnologis S.A.

InventorsChristophe Francois Aime Roca, Jose Manuel Bernardo Sousa, Marta Isabel Heitor Cerejo, Alexandra Maria Barros Dos Santos, Catia Santana Reverendo Rodrigues, Ricardo Filipe Antunes Pinheiro, Patricia Ramalhete Mendes da Silva Calado, Sukalyan Chatterjee, Helena Margarida Moreira de Oliveira Vieira

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Abstract

The present invention relates to a cell comprising an Endoplasmic Reticulum (ER) stress element operably linked to a reporter element and an exogenous gene encoding a protein that induces ER stress. Methods of screening using the modified cell, constructs used in the modified cell, the candidate agents identified by the screen and uses thereof are also part of the invention.

Claims20

Dependent claims

A cell comprising an ER stress sensor element operably linked to a reporter element and comprising an exogenous gene encoding a protein that induces ER stress.

Dependencies are inferred from the claim text.

Facts

Application

12/663,241Filed 6 Jun 2008

Priority

GB 0710976.27 Jun 2007

Published

26 Aug 2010

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Classification8 codes

G01N 33/502
For testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics: for testing non-proliferative effects
C12N 15/81
For fungi: for yeasts
G01N 33/5008
Involving human or animal cells: for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
C12N 2503/02
Use of cells in diagnostics: drug screening