Novel p2y12 receptor antagonists

A compound of Formula I:

• wherein:
• A and B are independently selected from the group consisting of CH2, O, S, NH, C═O, C═NH, C═S, or C═N—OH;
• X is selected from the group consisting of NH, O, S, C═O, and CH2;
• R1 and R2 are independently selected from the group consisting of hydrogen, unsubstituted or substituted C1-C10 alkyl, unsubstituted or substituted C1-C10 alkenyl, unsubstituted or substituted C1-C10 alkynyl, unsubstituted or substituted C3-C8 cycloalkyl, unsubstituted or substituted C1-C10 alkoxy, unsubstituted or substituted C3-C8 cycloalkoxy, unsubstituted or substituted C6-C14 aryl, an unsubstituted or substituted 5- to 10-membered heteroaryl wherein 1 to 4 ring atoms are independently selected from nitrogen, oxygen or sulfur, an unsubstituted or substituted 5- to 10-membered heteroalicyclic ring wherein 1 to 3 ring atoms are independently nitrogen, oxygen or sulfur, —OR, —C(O)R, —C(O)OR, —C(O)NRR′, —NRR′, —S(O)2R, —S(O)2OR, and —S(O)2NRR′;
• R3 is selected from the group consisting of hydrogen, unsubstituted or substituted C1-C10 alkyl, unsubstituted or substituted C1-C10 alkenyl, unsubstituted or substituted C1-C10 alkynyl, unsubstituted or substituted C3-C8 cycloalkyl, unsubstituted or substituted C1-C10 alkoxy, unsubstituted or substituted C3-C8 cycloalkoxy, unsubstituted or substituted C6-C14 aryl, an unsubstituted or substituted 5- to 10-membered heteroaryl wherein 1 to 4 ring atoms are independently selected from nitrogen, oxygen or sulfur, an unsubstituted or substituted 5- to 10-membered heteroalicyclic ring wherein 1 to 3 ring atoms are independently nitrogen, oxygen or sulfur, alkylaryl, alkylheteroaryl, an unsubstituted or substituted 7 to 12-membered bicyclic alkyl or heterocyclic ring wherein 1 to 3 ring members are independently nitrogen, oxygen or sulfur, an unsubstituted or substituted 10 to 16-membered tricyclic alkyl or heterocyclic ring wherein 1 to 3 ring members are independently nitrogen, oxygen or sulfur,
• R4 and R5 are hydrogen, or, combined, R4 and R5 may form, together with the carbon atoms to which they are attached, a group selected from the group consisting of unsubstituted or substituted C3-C8 cycloalkyl, unsubstituted or substituted C6-C14 aryl, unsubstituted or substituted 5- to 10-membered heteroaryl wherein 1 to 4 ring atoms are independently selected from nitrogen, oxygen or sulfur, or unsubstituted or substituted 5- to 10-membered heteroalicyclic ring wherein 1 to 3 ring atoms are independently nitrogen, oxygen or sulfur;
• R6 represents one to four substituents independently selected from the group consisting of hydrogen, halogen, unsubstituted or substituted C1-C4 alkyl, alkenyl or alkynyl, an unsubstituted or substituted 5- to 10-membered heteroaryl wherein 1 to 4 ring atoms are independently selected from nitrogen, oxygen or sulfur, an unsubstituted or substituted 5- to 10-membered heteroalicyclic ring wherein 1 to 3 ring atoms are independently nitrogen, oxygen or sulfur, —OR, —NRR′, —NO2, unsubstituted or substituted C1-C4 alkoxy, —C(O)R, —C(O)OR, —C(O)NRR′, —S(O)2R, —S(O)2OR, and —S(O)2NRR′;
• Y is selected from the group consisting of hydrogen, halogen, NH, O, S, CH2, CH2CH2, C(O), C(O)O, S(O)2O, or unsubstituted C1-C4 alkoxy, wherein when Y is hydrogen, halogen or alkoxy R7 is missing;
• R7 is selected from the group consisting of hydrogen, halogen, —OR, unsubstituted or substituted C1-C10 alkyl, alkenyl or alkynyl, unsubstituted or substituted C1-C10 alkoxy, unsubstituted or substituted C3-C8 cycloalkoxy, unsubstituted or substituted C3-C8 cycloalkyl, unsubstituted or substituted C6-C14 aryl, an unsubstituted or substituted 5- to 10-membered heteroaryl wherein 1 to 4 ring atoms are independently selected from nitrogen, oxygen or sulfur, an unsubstituted or substituted 5- to 10-membered heteroalicyclic wherein 1 to 3 ring atoms are independently nitrogen, oxygen or sulfur, —C(O)R, —C(O)OR, —C(O)NRR′, —NRR′, —S(O)2R, —S(O)2OR, —S(O)2NRR′, and —P(O)RR′;
• and
• R and R′ are independently selected from the group consisting of hydrogen and unsubstituted C1-C4 alkyl;
• or a pharmaceutically acceptable salt or prodrug thereof.