Pharmaceutical compositions comprising dextran with a molecular weight of 1.0-100 kda and processes for their preparation
AssigneeTechnology Development Corporation
InventorVladimir A. Sabetsky
Life of this patent
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Abstract
A solid or semisolid implant obtainable by providing a liquid composition comprising an aqueous solution of dextran with molecular weight of 1.0-100 kDa and introducing the liquid composition into the body of a mammal, whereby the implant is formed in situ in the body of the mammal. A process for preparing a composition useful for biomedical application, comprising the steps of providing a liquid composition comprising an aqueous solution of dextran having a molecular weight of 1-100 kDa; and bringing the liquid composition to solidify; whereby water is gradually eliminated from the liquid composition during the solidification. A biomedical article prepared from the composition.
Claims28
A solid or semisolid implant obtainable by providing a liquid composition comprising an aqueous solution of dextran with molecular weight of 1.0-100 kDa at a concentration within the range of 25-75% by weight and introducing the liquid composition into the body of a mammal, whereby said implant is formed in situ in the body of said mammal.
A process for preparing a composition, said composition being suitable for the controlled release of a biologically active protein in the body of a mammal, said process comprising:
- a. providing an aqueous solution of dextran having a molecular weight of 1-100 kDa at a concentration within the range of 25-75% by weight;
- b. introducing a biologically active protein into the aqueous solution of (a) to form a liquid composition;
- and
- c. forming a solid matrix from said dextran in said liquid composition by bringing said dextran in said liquid composition to a solid form by gradually eliminating water from said liquid composition by evaporation or extraction, thereby providing a composition in which said biologically active protein is contained within said solid matrix.
Dependencies are inferred from the claim text.