# US 2010/0168807 A1 · Bioactive terpolymer compositions and methods of making and using same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2010/0168807 A1 - Document ID: US20100168807A1 - Status: Published application - Kind: A1 - Application number: 12/644,097 - Filed: 2009-12-22 - Published: 2010-07-01 - Earliest claimed: 2008-12-23 - Inventors: Kevin W. Burton; Howard Bowman; Danielle Biggs; Peter Markland - Web page: https://patentgrep.com/patent/US20100168807A1 ## CPC - A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) - A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)} - A61K 31/56: Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids - A61L 27/34: Macromolecular materials - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 31/10: Macromolecular materials - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - A61M 5/19: having more than one chamber - A61N 1/37512: {Pacemakers} - A61L 2300/622: Microcapsules - A61N 1/375: Constructional arrangements, e.g. casings - A61N 1/3968: {Constructional arrangements, e.g. casings (A61N1/375 takes precedence)} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Described herein are terpolymer compositions, kits comprising the compositions, implant devices comprising the compositions, and methods of making and using same, including point of use methods. ## Claims ### Claim 1 A bioactive agent delivery composition comprising: an adhering biocompatible terpolymer and a releasable bioactive agent. ### Claim 2 (depends on 1) The composition of claim 1, wherein the terpolymer comprises at least one of lactide, glycolide, caprolactone, optionally endcapped polyethylene glycol (PEG), or a combination thereof. ### Claim 3 (depends on 1) The composition of claim 1, wherein the terpolymer comprises lactide, glycolide, and caprolactone residues, and wherein the terpolymer comprises an end group that is a residue of an initiator that is a non-crystalline primary or secondary alcohol. ### Claim 4 (depends on 1) The composition of claim 1, wherein the terpolymer comprises at least one of poly(lactide-co-glycolide-co-optionally endcapped PEG), or poly(lactide-co-glycolide-co-caprolactone), or a combination thereof. ### Claim 5 (depends on 1) The composition of claim 1, wherein the bioactive agent is encapsulated within a microparticle. ### Claim 6 (depends on 1) The composition of claim 1, wherein the bioactive agent comprises at least one of an antimicrobial, an antibiotic, a growth factor, a growth inhibitor, an immunomodulator, a steroid, or an anti-inflammatory. ### Claim 7 A kit comprising an adhering biocompatible terpolymer and a bioactive agent. ### Claim 8 (depends on 7) The kit of claim 7, wherein the terpolymer and bioactive agent are separated. ### Claim 9 (depends on 7) The kit of claim 7, wherein the terpolymer is present in a first container, and the bioactive agent is present in a second container. ### Claim 10 (depends on 7) The kit of claim 7, wherein the terpolymer is present in a first dispensing system, and the bioactive agent is present in a second dispensing system. ### Claim 11 (depends on 10) The kit of claim 10, wherein at least one of the first dispensing system or the second dispensing system comprises a syringe. ### Claim 12 (depends on 7) The kit of claim 7, wherein the terpolymer comprises at least one of lactide, glycolide, caprolactone, optionally endcapped polyethylene glycol (PEG), or a combination thereof. ### Claim 13 (depends on 7) The kit of claim 7, wherein the terpolymer comprises lactide, glycolide, and caprolactone residues, and wherein the terpolymer comprises an end group that is a residue of an initiator that is a non-crystalline primary or secondary alcohol. ### Claim 14 (depends on 7) The kit of claim 7, wherein the bioactive agent is encapsulated within a microparticle. ### Claim 15 (depends on 7) The kit of claim 7, wherein the bioactive agent comprises at least one of an antibiotic, a growth factor, an immunomodulator, a steroid, or an anti-inflammatory. ### Claim 16 An implant device having a first implant device surface comprising a composition comprising an adhering biocompatible terpolymer and a releasable bioactive agent, wherein the composition is present on at least a portion of the first implant device surface. ### Claim 17 (depends on 16) The implant device of claim 16, wherein the implant device is implanted in a subject. ### Claim 18 (depends on 16) The implant device of claim 16, wherein the implant device comprises a pump, pacemaker, defribrillator, or stimulator.