# US 2010/0168648 A1 · System and method for transfetal (amnion-chorion) membranes transport > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2010/0168648 A1 - Document ID: US20100168648A1 - Status: Published application - Kind: A1 - Application number: 12/308,244 - Filed: 2007-06-13 - Published: 2010-07-01 - Earliest claimed: 2006-06-13 - Assignees: Ben-Gurion University of the Negev Research and Development Authority - Inventors: Joseph Kost; Israel Patla; AVraham Schroeder; Lior Wolloch; Mordechi Hallak - Web page: https://patentgrep.com/patent/US20100168648A1 ## CPC - A61B 10/0045: {Devices for taking samples of body liquids} - A61M 37/0092: {using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis} - A61B 10/0048: {for taking amniotic fluid samples} - A61B 2017/00026: {Conductivity or impedance, e.g. of tissue} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract The invention provides a system and method for trans-fetal membranes transport. A source of ultrasound sonication is used to deliver ultrasound sonication to fetal membranes to enhance the permeability of the fetal membranes of a gestational sac. In one embodiment, a device is used to collect substances transported from the interior of the gestational sac to the exterior of the gestational sac, such as amniotic or coelomic fluid. In another embodiment a device is used to deliver one or more substances, such as a drug, to an external surface of the fetal membranes. ## Claims ### Claim 1 A system for trans-fetal membranes transport comprising: (a) A source of ultrasound sonication configured to deliver ultrasound sonication to fetal membranes to enhance the permeability of the fetal membranes of a gestational sac; and (b) a device selected from: a device adapted to collect substances transported from an interior of the gestational sac to an exterior of the gestational sac; and a device to deliver one or more substances to an external surface of the fetal membranes. ### Claim 2 (depends on 1) The system according to claim 1 comprising a probe unit containing the ultrasound source adapted to be inserted into a vagina. ### Claim 3 (depends on 1) The system according to claim 1 wherein the probe unit is adapted to be inserted into a cervix. ### Claim 4 (depends on 1) The system according to claim 1 wherein the probe unit is configured to deliver an acoustic coupling material to a distal end of the probe unit. ### Claim 5 (depends on 1) The system according to claim 1 comprising a device adapted to collect substances transported from an interior of the gestational sac to an exterior of the gestational sac. ### Claim 6 (depends on 5) The system according to claim 5 wherein the device is adapted to collect substances transported from an interior of the gestational sac to an exterior of the gestational sac comprises a receptacle collecting substances transported from the interior of the gestational sac to an exterior of the gestational sac. ### Claim 7 (depends on 5, 6) The system according to claim 5 or 6 wherein the device is adapted to collect substances transported from an interior of the gestational sac to an exterior of the gestational sac comprises a vacuum system drawing substance away from the fetal membranes. ### Claim 8 (depends on 5, 6) The system according to claim 5 or 6 wherein the device is adapted to collect substances transported from an interior of the gestational sac to an exterior of the gestational sac comprises a high osmotic solution. ### Claim 9 (depends on 1) The system according to claim 1 comprising a device to deliver one or more substances to an external surface of the fetal membranes. ### Claim 10 (depends on 9) The system according to claim 9 wherein the device to deliver one or more substances to an external surface of the fetal membranes comprises a piston. ### Claim 11 The system according to any one of the previous claims further comprising a control unit. ### Claim 12 The system according to any one of the previous claims further comprising an electrical conductivity, system measuring electrical conductivity of the fetal membranes. ### Claim 13 A method for trans-fetal membranes transport comprising: (a) delivering ultrasound sonication to the fetal membranes of a gestational sac to increase a permeability of the fetal membranes; and (b) collecting substances transported from an interior of the gestational sac to an exterior of the gestational sac or delivering one or more substances to an external surface of the fetal membranes. ### Claim 14 (depends on 13) The method according to claim 13 wherein the ultrasound sonication is delivered using an ultrasound source inserted into a vagina. ### Claim 15 (depends on 13) The method according to claim 13 wherein the ultrasound sonication is delivered using an ultrasound source inserted into a cervix. ### Claim 16 (depends on 13) The method according to claim 13 further comprising delivering an acoustic coupling material between the ultrasound source and a body tissue. ### Claim 17 (depends on 13) The method according to claim 13 further comprising collecting one or more substances transported from an interior of the gestational sac to an exterior of the gestational sac. ### Claim 18 (depends on 17) The method according to claim 17 wherein the substances are collected in a receptacle positioned in a vagina or a cervix. ### Claim 19 (depends on 17, 18) The method according to claim 17 or 18 further comprising drawing substance away from the fetal membranes by a vacuum. ### Claim 20 (depends on 17, 18) The method according to claim 17 or 18 further comprising drawing substance away from the fetal membranes by a high osmotic solution. ### Claim 21 (depends on 17, 18, 19, 20) The method according to any one of claims 17 to 20 wherein the one or more substances is an amniotic fluid or a coelomic fluid. ### Claim 22 (depends on 13) The method according to claim 13 comprising delivering one or more substances to an external surface of the fetal membranes. ### Claim 23 (depends on 21) The method according to claim 21 wherein the one or more substances are delivered to an external surface of the fetal membranes under pressure. ### Claim 24 (depends on 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23) The method according to any one of claims 13 to 23 wherein a substance is transported across the fetal membrane by diffusion. ### Claim 25 (depends on 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24) The method according to any one of claims 13 to 24 further comprising monitoring electrical conductivity of the fetal membranes.