# US 2010/0168609 A1 · Biopsy device for the enrichment of tissue, cells, or analytes > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2010/0168609 A1 - Document ID: US20100168609A1 - Status: Published application - Kind: A1 - Application number: 12/530,945 - Filed: 2008-03-14 - Published: 2010-07-01 - Earliest claimed: 2007-03-14 - Assignees: Ogeno GmbH - Inventors: Ulrich Pison; Axel Schaefer - Web page: https://patentgrep.com/patent/US20100168609A1 ## CPC - A61B 10/02: Instruments for taking cell samples or for biopsy {(A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48)} - A61B 10/00: Instruments for taking body samples for diagnostic purposes (for taking samples of blood A61B5/15); Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements - G01N 33/553: Metal or metal coated - A61B 2017/00831: {Material properties} - A61B 2017/00893: {pharmaceutically effective} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract The invention relates to a biopsy device for the in vivo enrichment of tissue, cells, or analytes, including drugs and therapeutic active substances, at the site of biopsy and for subsequent testing. ## Claims ### Claim 1 A biopsy device comprising said device and wherein the device or part of the device is electroplated with gold or metals preferably from group 10 or 11 of the periodic table of the elements, wherein the device is for in vivo enrichment of tissue, cells, or analytes, including drugs and therapeutic active substances, at the site of biopsy for subsequent testing. ### Claim 2 (depends on 1) A biopsy device according to claim 1, wherein the device or part of the device is modified with metals preferably from group 10 or 11 of the periodic table of elements using evaporation techniques. ### Claim 3 (depends on 1) A biopsy device according to claim 1, wherein the device or part of the device is modified with metals preferably from group 10 or 11 of the periodic table of elements using ceramic techniques. ### Claim 4 (depends on 1) A biopsy device according to claim 1, wherein the device or part of the device is modified with metals preferably from group 10 or 11 of the periodic table of elements using cementation techniques. ### Claim 5 (depends on 1, 2, 3, 4) A biopsy device according to claims 1 to 4, wherein the surface is further modified using anodic oxidation. ### Claim 6 (depends on 1) A biopsy device according to claim 1, wherein the device or parts thereof are not treated with nanotechnology or do not feature nanostructures which are obtained by nanotechnological methods. ### Claim 7 A biopsy device comprising a device and wherein the device or part of the device is modified with collagen pads and wherein the device is for in vivo enrichment of stem cells and others, including drugs and therapeutic active substances, at the site of biopsy for subsequent culturing or testing. ### Claim 8 (depends on 1, 7) A biopsy device according to claim 1 or claim 7, wherein the device has an outer form of a cylinder or a tube with a diameter ranging from 0.01 mm to 10 mm, preferably from 0.1 to 2 mm, most preferably from 0.25 mm to 0.8 mm. ### Claim 9 (depends on 1) A biopsy device according to claim 1, wherein the device has a length between 0.5 mm to 300 mm, preferably between 10 mm to 100 mm, most preferably between 25 mm to 80 mm. ### Claim 10 (depends on 1, 7) A biopsy device according to claim 1 or 7, wherein dimensions or core materials of the biopsy device are spring wires, flexible plastic rods, catheters, and/or stents. ### Claim 11 (canceled) ### Claim 12 (depends on 1) A biopsy device according to claim 1, wherein the device is decorated with a specific ligand selected from a group consisting of antibodies, parts thereof, or sequences, which are not antibodies or parts thereof, having high binding affinity to tissue, cells, or analytes of interest located at the site of biopsy. ### Claim 13 (depends on 1) A biopsy device according to claim 1 with a surface that is further modified using imprint techniques to serve as a corresponding binding structure for a target. ### Claim 14 (depends on 1) A biopsy device according to claim 1 that is to be placed inside a body of an animal or human for a defined period of time, wherein the a location for placing the device in vivo is preferably solid tissue, more preferably a cavity of the body like the peritoneum or uterus or gastro intestinal tract, most preferably the lumen of artery or vein, or the ureter, or vasa lymphatica, or ductus choledochus, or ductus pancreaticus, or the spinal canal. ### Claim 15 (depends on 14) A biopsy device according to claim 14, wherein the period of time in vivo is determined by the a concentration of the a material of interest and the a binding affinity between the ligand and the material of interest. ### Claim 16 (depends on 1) A biopsy device according to claim 1 that is magnetic and thus could attracts magnetic particles. ### Claim 17 (depends on 7) A biopsy device according to claim 7, wherein the a period of time in vivo within which the device is placed inside a body of an animal or human is determined by a concentration of a material of interest and a binding affinity between the collagen pad and the material of interest. ### Claim 18 (depends on 13) A biopsy device according to claim 13, wherein a period of time in vivo within which the device is placed inside a body of an animal or human is determined by a concentration of the a material of interest and the a binding affinity between the imprinted structure of the a tip of the device and the material of interest.