# US 2010/0168443 A1 · Ethoid-Containing Compounds, Methods for Preparing Ethoid-Containing Compounds, and Methods of Use

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- Number: US 2010/0168443 A1
- Document ID: US20100168443A1
- Status: Published application
- Kind: A1
- Application number: 12/513,210
- Filed: 2007-11-02
- Published: 2010-07-01
- Earliest claimed: 2006-11-02
- Assignees: University of Virginia Patent Foundation
- Inventors: Hendrik Mario Geysen
- Web page: https://patentgrep.com/patent/US20100168443A1

## CPC

- A61K 31/785: Polymers containing nitrogen
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Ethoid-containing compounds comprising one or more ethoid moieties (e.g., a methyleneoxy, Ψ[CH2O]) as a substitutive, isosteric replacement for an amide moiety of a polyaminoacid are disclosed. Universal, modular approaches for preparing such ethoid-containing compounds are also disclosed. Such ethoid-containing compounds can be polyaminoacid analogs, and are useful as food additives, as cosmetics ingredients, as research reagents, as diagnostic agents, and as therapeutic agents.

## Claims

### Claim 1

A compound comprising a polyethoid moiety having a formula
wherein:
m is an integer ≧0;
each a is an independently selected integer=1 or =2;
R1, each R2 and R4 are each (i) an independently selected side chain moiety selected from the group consisting of H, C1-C10 alkyl and substituted C1-C10 alkyl, which in each case can optionally form one or more ring structures, or (ii) an independently selected side chain moiety having a structure of an amino acid side chain;
R3 is (a) a side chain moiety selected from the group consisting of RC, RD, RE, RF, RH, RI, RK, RL, RM, RN, RP, RQ, RR, RT, RU, RV, RW and RY, each as delineated in Table I.A, (b) a side chain moiety selected from and having a structure of a non-natural amino acid side chain as delineated in Table I.B.1 or in Table I.C.1 or (c) a protected derivative of the foregoing side chain moieties;
R1′, each R2′, R3′ and R4′ are each independently selected from the group consisting of H, C1-C3 alkyl and substituted C1-C3 alkyl;
each R10 is independently selected from the group consisting of H, C1-C3 alkyl and substituted C1-C3 alkyl;
each V is independently selected from the group consisting of —C(O)NH— and -ψ[ ]-; and
Y and Z are each independently selected from the group consisting of H, hydrocarbyl and substituted hydrocarbyl.

### Claim at position 2

-1126. (canceled)