# US 2010/0168249 A1 · Composition containing reduced coenzyme q10, and method for stabilizing the composition

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- Number: US 2010/0168249 A1
- Document ID: US20100168249A1
- Status: Published application
- Kind: A1
- Application number: 12/710,888
- Filed: 2010-02-23
- Published: 2010-07-01
- Earliest claimed: 2007-08-23
- Assignees: Kaneka Corporation
- Inventors: Shiro KITAMURA; Takahiro UEDA
- Web page: https://patentgrep.com/patent/US20100168249A1

## CPC

- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A21D 2/14: Organic oxygen compounds
- A21D 2/165: {Triglycerides}
- A23D 7/0053: {Compositions other than spreads}
- A23D 7/0056: {Spread compositions}
- A23D 9/007: characterised by ingredients other than fatty acid triglycerides
- A23D 9/013: Other fatty acid esters, e.g. phosphatides
- A23K 20/111: Aromatic compounds
- A23K 20/158: Fatty acids; Fats; Products containing oils or fats
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A23L 33/12: Fatty acids or derivatives thereof
- A61K 8/355: {Quinones}
- A61Q 19/00: Preparations for care of the skin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A21D: TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS (preservation of flour or dough before baking A23B40/00; preservation of bakery products A23B45/00)
- A23D: EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS (preservation thereof A23B20/00; production, refinement or preservation of animal or vegetable fats or oils C11B, C11C)
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention provides a composition containing reduced coenzyme Q10, which is useful as a pharmaceutical product, food, cosmetic, animal drug, feed, and the like, as well as a stabilization method thereof. The oxidation of reduced coenzyme Q10 into oxidized coenzyme Q10 by molecular oxygen can be suppressed by setting, in a composition containing reduced coenzyme Q10 and at least one kind of oil component selected from the group consisting of fat, oil, a mixture thereof, fatty acid, wax and a surfactant, the weight ratio of the reduced coenzyme Q10 to the oil component to not less than 1/4 when the composition is a liquid, and not less than 1/9 when the composition is a solid.

## Claims

### Claim 1

A liquid composition comprising reduced coenzyme Q10 and at least one kind of oil component selected from the group consisting of fat, oil, a mixture thereof, fatty acid, wax and a surfactant, wherein the weight ratio of the reduced coenzyme Q10 to the oil component is not less than 1/4.

### Claim 2 (depends on 1)

The composition according to claim 1, wherein the fat, oil or a mixture thereof is at least one kind selected from the group consisting of coconut oil, palm oil, palm kernel oil, flaxseed oil, camellia oil, brown rice germ oil, canola oil, rice oil, peanuts oil, corn oil, wheat germ oil, soybean oil, perilla oil, cottonseed oil, sunflower oil, kapok oil, evening primrose oil, Shea butter, sal butter, cacao butter, sesame oil, safflower oil, olive oil, lard, milk fat, fish oil, beef fat, medium-chain triglyceride, and fat, oil and a mixture of fat and oil obtained by processing them.

### Claim 3 (depends on 1)

The composition according to claim 1, wherein the fatty acid is at least one kind selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, behenic acid, linoleic acid, linolenic acid and esters thereof.

### Claim 4 (depends on 1)

The composition according to claim 1, wherein the wax is at least one kind selected from the group consisting of beeswax, rice bran wax, carnauba wax, candelilla wax, sugar cane wax, shellac wax and jojoba wax.

### Claim 5 (depends on 1)

The composition according to claim 1, wherein the surfactant is at least one kind selected from the group consisting of partial glyceride of fatty acid, propylene glycol ester of fatty acid, phospholipid, sucrose ester of fatty acid, sorbitan ester of fatty acid, polyoxyethylene sorbitan fatty acid ester, polyglycerol ester of fatty acid and polyglycerol ester of condensed ricinoleic acid.

### Claim 6 (depends on 1)

The composition according to claim 1, which is filled in a container.

### Claim 7 (depends on 6)

The composition according to claim 6, wherein the weight thereof per one package unit is not less than 1 kg.

### Claim 8

A solid composition comprising reduced coenzyme Q10 and at least one kind of oil component selected from the group consisting of fat, oil, a mixture thereof, fatty acid, wax and a surfactant, wherein the weight ratio of the reduced coenzyme Q10 to the oil component is not less than 1/9.

### Claim 9 (depends on 8)

The composition according to claim 8, wherein the fat, oil or a mixture thereof is at least one kind selected from the group consisting of coconut oil, palm oil, palm kernel oil, flaxseed oil, camellia oil, brown rice germ oil, canola oil, rice oil, peanuts oil, corn oil, wheat germ oil, soybean oil, perilla oil, cottonseed oil, sunflower oil, kapok oil, evening primrose oil, shea butter, sal butter, cacao butter, sesame oil, safflower oil, olive oil, lard, milk fat, fish oil, beef fat, medium-chain triglyceride, and fat, oil and a mixture of fat and oil obtained by processing them.

### Claim 10 (depends on 8)

The composition according to claim 8, wherein the fatty acid is at least one kind selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, behenic acid, linoleic acid, linolenic acid and esters thereof.

### Claim 11 (depends on 8)

The composition according to claim 8, wherein the wax is at least one kind selected from the group consisting of beeswax, rice bran wax, carnauba wax, candelilla wax, sugar cane wax, shellac wax and jojoba wax.

### Claim 12 (depends on 8)

The composition according to claim 8, wherein the surfactant is at least one kind selected from the group consisting of partial glyceride of fatty acid, propylene glycol ester of fatty acid, phospholipid, sucrose ester of fatty acid, sorbitan ester of fatty acid, polyoxyethylene sorbitan fatty acid ester, polyglycerol ester of fatty acid and polyglycerol ester of condensed ricinoleic acid.

### Claim 13 (depends on 8)

The composition according to claim 8, having a volume of not less than 0.02 cm3.

### Claim 14 (depends on 8)

The composition according to claim 8, which is packed with a film.

### Claim 15 (depends on 8)

The composition according to claim 8, which is filled in a container.

### Claim 16 (depends on 15)

The composition according to claim 15, wherein the weight thereof per one package unit is not less than 1 kg.

### Claim 17

A composition comprising reduced coenzyme Q10 and fatty acid and/or diglyceride, wherein the reduced coenzyme Q10 is obtained by reducing oxidized coenzyme Q10 in the composition.

### Claim 18 (depends on 17)

The composition according to claim 17, wherein the fatty acid is at least one kind selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, behenic acid, linoleic acid, linolenic acid and esters thereof.

### Claim 19 (depends on 17)

The composition according to claim 17, wherein the diglyceride is at least one kind selected from the group consisting of monoglycerol dicaprylate, monoglycerol dicaprate, monoglycerol dilaurate, monoglycerol dimyristate, monoglycerol dipalmitate, monoglycerol distearate, monoglycerol dioleate, monoglycerol dilinoleate, monoglycerol dilinolenate, monoglycerol dibehenate and monoglycerol dierucate.

### Claim 20 (depends on 17)

The composition according to claim 17, wherein the weight ratio of the total amount of reduced coenzyme Q10 and oxidized coenzyme Q10 to the (total) amount of fatty acid and/or diglyceride is not less than 1/19.

### Claim 21 (depends on 17)

The composition according to claim 17, which is a solid.