# US 2010/0168247 A1 · Solid composites of a calcium receptor-active compound

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- Number: US 2010/0168247 A1
- Document ID: US20100168247A1
- Status: Published application
- Kind: A1
- Application number: 12/723,268
- Filed: 2010-03-12
- Published: 2010-07-01
- Earliest claimed: 2006-09-01
- Assignees: Teva Pharmaceutical Industries Ltd.
- Inventors: Ilan Zalit; Uri Zadok
- Web page: https://patentgrep.com/patent/US20100168247A1

## CPC

- A61K 31/135: having aromatic rings {, e.g. ketamine, nortriptyline (methadone A61K31/137)}
- A61K 9/146: {with organic macromolecular compounds}
- A61K 9/2077: {Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets}
- A61P 5/18: of the parathyroid hormones
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention encompasses solid composites of the calcium receptor-active compounds, processes for preparing the solid composites, immediate and controlled-release pharmaceutical formulations comprising the solid composites, and methods of treatment therewith.

## Claims

### Claim 1

A method for preparing a solid composite, comprising:
combining cinacalcet, at least one carrier, and at least one liquid solvent to form a solution; and
removing the solvent to obtain a solid composite of the cinacalcet and the at least one carrier.

### Claim 2 (depends on 1)

The method of claim 1, wherein the solid composite is a solid solution.

### Claim 3 (depends on 1)

The method of claim 1, wherein the carrier is selected from the group consisting of povidone, poloxamer, hydroxypropyl methylcellulose, polyethylene glycol, copovidone, copolymers of methacrylate, and copolymers of methacrylic acid.

### Claim 4 (depends on 1)

The method of claim 1, further comprising removing solvent by evaporation.

### Claim 5 (depends on 1)

The method of claim 1, further comprising dissolving the cinacalcet and at least one carrier in an organic or inorganic solvent to form the solution;
adding a supercritical fluid to induce precipitation of a mixture of the cinacalcet and the carrier; and
removing the solvent and the supercritical fluid by evaporation.

### Claim 6 (depends on 1)

The method of claim 1, wherein the solvent is a supercritical fluid.

### Claim 7 (depends on 6)

The method of claim 6, wherein the supercritical fluid is selected from the group consisting of carbon dioxide, water, methane, ethane, propane, ethylene, propylene, methanol, ethanol, and acetone.

### Claim 8 (depends on 6)

The method of claim 6, further comprising removing the supercritical fluid by reducing pressure.

### Claim 9

A method for preparing a solid composite, comprising:
combining cinacalcet and at least one carrier to form a mixture;
heating the mixture to a temperature at which both the cinacalcet and the carrier melt to form a fusion product; and
cooling the fusion product in a manner that does not allow crystallization of the cinacalcet out of the fusion product.

### Claim 10 (depends on 9)

The method of claim 9, further comprising combining the cinacalcet and at least one carrier to form a mixture;
heating the mixture to control its viscosity; and
feeding the heated mixture through a hot melt extrusion system.