# US 2010/0168241 A1 · Treatment of acne disease states, notably acne vulgaris

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- Number: US 2010/0168241 A1
- Document ID: US20100168241A1
- Status: Published application
- Kind: A1
- Application number: 12/612,414
- Filed: 2009-11-04
- Published: 2010-07-01
- Earliest claimed: 2007-05-04
- Assignees: Galderma Research & Development
- Inventors: Lucy COLON
- Web page: https://patentgrep.com/patent/US20100168241A1

## CPC

- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 41/0038: {Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy (radiotherapy per se A61N5/10)}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 17/10: Anti-acne agents
- A61N 5/062: {Photodynamic therapy, i.e. excitation of an agent}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Acne disease states, notably acne vulgaris, are treated with naphthoic acid compounds and particularly adapalene in association/combination with light therapy.

## Claims

### Claim 1

A regime or regimen for inhibiting or treating an acne disease state afflicting the skin of an individual subject, comprising topically applying onto such afflicted skin a thus effective amount of a naphthoic acid compound and thereafter exposing such treated skin to red and/or blue light.

### Claim 2 (depends on 1)

The regime or regimen as defined by claim 1, wherein said acne disease state comprises acne vulgaris.

### Claim 3 (depends on 1)

A regimen as defined by claim 1, wherein treatment with naphthoic acid compound and light exposure is carried out at least once per day from every two days to once a week.

### Claim 4 (depends on 1)

A regimen as defined by claim 1, wherein treatment with naphthoic acid compound and light exposure is carried out once per day twice a week.

### Claim 5 (depends on 1)

The regime or regimen as defined by claim 1, wherein naphthoic acid compound treated afflicted skin is exposed to blue light first and red light thereafter.

### Claim 6 (depends on 5)

A regimen as defined by claim 5, wherein naphthoic acid compound treated afflicted skin is exposed to blue light the first week and the red light exposure is carried out the weeks following.

### Claim 7 (depends on 1)

The regime or a regimen as defined by claim 1, wherein blue light is emitted with wavelengths ranging from 405 nm to 420 nm.

### Claim 8 (depends on 1)

The regime or a regimen as defined by claim 1, wherein red light is emitted with wavelengths ranging from 620 nm to 650 nm.

### Claim 9 (depends on 1)

A regimen as defined by claim 1, wherein treatment with naphthoic acid compound and light exposure is carried out for at least 3 weeks.

### Claim 10 (depends on 1)

A regimen as defined by claim 1, wherein treatment with naphthoic acid compound and light exposure is carried out on skin of the face, trunk and/or back.

### Claim 11 (depends on 1)

The regime or regimen as defined by claim 1, wherein said naphthoic acid compound comprises adapalene.

### Claim 12 (depends on 11)

The regime or a regimen as defined by claim 11, wherein said naphthoic acid compound comprises adapalene 0.1%.

### Claim 13

A regime or regimen for treating a patient afflicted with an acne disease state, including acne vulgaris, comprising administering to such patient an effective amount of naphthoicadapalene in association/combination with red and/or blue light exposure.

### Claim 14 (depends on 1)

The regime or regimen as defined by claim 1, said naphthoic acid compound comprising an aqueous gel composition.

### Claim 15 (depends on 14)

The regime or regimen as defined by claim 14, said naphthoic acid compound comprising adapalene.