# US 2010/0168224 A1 · Hypoglycemic Activity of Osthole

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- Number: US 2010/0168224 A1
- Document ID: US20100168224A1
- Status: Published application
- Kind: A1
- Application number: 12/347,429
- Filed: 2008-12-31
- Published: 2010-07-01
- Earliest claimed: 2008-12-31
- Assignees: Taipei Medical University
- Inventors: Yu-Chih Liang; Der-Zen Liu; Ling-Fang Hung; Pei-Jung Lin; Nai-Qi Chen; Yu-Chien Chen
- Web page: https://patentgrep.com/patent/US20100168224A1

## CPC

- A61K 31/352: condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)}
- A61P 3/08: for glucose homeostasis (pancreatic hormones A61P5/48)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a method for controlling blood glucose level and a method for the prophylaxis or treatment of diabetes mellitus and/or its complications. The present invention further relates to an anti-diabetic formulation for controlling blood glucose level and/or for the prophylaxis or treatment of diabetes mellitus and/or its complications.

## Claims

### Claim 1

A method for controlling blood glucose level comprising administering a therapeutically effective amount of osthole or a pharmaceutically acceptable derivative thereof to a subject in need thereof, thereby reducing the blood glucose level in the subject.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the therapeutically effective amount is about 10 to about 200 mg/kg/day.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the therapeutically effective amount is about 50 mg/kg/day.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the osthole or pharmaceutically acceptable derivative thereof is administered to the subject parenterally or orally.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the subject is a mammal.

### Claim 6 (depends on 6)

The method according to claim 6, wherein the mammal is a human.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the blood glucose level is elevated due to diabetes mellitus.

### Claim 8 (depends on 1)

The method according to claim 1, further comprising administering a second agent effective for controlling blood glucose level.

### Claim 9 (depends on 1)

The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained by chemically synthesized or extracted from osthole-containing plants.

### Claim 10 (depends on 1)

The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium plant.

### Claim 11 (depends on 1)

The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium monnieri (L.) Cuss.

### Claim 12 (depends on 1)

The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium fruit.

### Claim 13

A method for the prophylaxis or treatment of diabetes mellitus and/or its complications comprising administering a therapeutically effective amount of osthole or a pharmaceutically acceptable derivative thereof to a subject in need thereof.

### Claim 14 (depends on 13)

The method according to claim 13, wherein the therapeutically effective amount is about 10 to about 200 mg/kg/day.

### Claim 15 (depends on 13)

The method according to claim 13, wherein the therapeutically effective amount is about 50 mg/kg/day.

### Claim 16 (depends on 13)

The method according to claim 13, wherein the osthole or pharmaceutically acceptable derivative thereof is administered to the subject parenterally or orally.

### Claim 17 (depends on 13)

The method according to claim 13, wherein the subject is a mammal.

### Claim 18 (depends on 13)

The method according to claim 13, wherein the mammal is a human.

### Claim 19 (depends on 13)

The method according to claim 13, wherein the diabetes mellitus is Type I.

### Claim 20 (depends on 13)

The method according to claim 13, wherein the diabetes mellitus is Type II.

### Claim 21 (depends on 13)

The method according to claim 13, further comprising administering a second agent effective for the prophylaxis or treatment of diabetes mellitus.

### Claim 22 (depends on 13)

The method according to claim 13, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained by chemically synthesized or extracted from osthole-containing plants.

### Claim 23 (depends on 13)

The method according to claim 13, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium plant.

### Claim 24 (depends on 13)

The method according to claim 13, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium monnieri (L.) Cuss.

### Claim 25 (depends on 13)

The method according to claim 13, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium fruit.