Hereditary cataract status in canines based on hsf4 gene marker
AssigneeAnimal Health Trust
InventorsCathryn Suzanne Mellersh, Mark Vaudin
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Abstract
The invention provides methods for assessing the Hereditary cataract (HC) status of a canine mammal, which methods comprise use of an HSF4 marker to assess the status. Preferred canine mammals are dogs selected from the following breeds: Staffordshire bull terrier, Boston terrier, French bulldog, Mastiff, Bulldog, Boxer, Bullmastiff, Miniature bull terrier.
Claims27
A method for assessing the Hereditary cataract (HC) status of a canine mammal, the method comprising using an HSF4 marker to assess the status.
A method as claimed in any one of the preceding claims wherein the HSF4 marker is a functional mutation which is causative of the HC condition.
A method as claimed in any one of the preceding claims wherein the HSF4 marker is present in exon 9 of the HSF4 gene, wherein exon 9 is as defined between nucleotides 2931-2957 of sequence Annex I.
A primer pair for use in a method for assessing the Hereditary cataract (HC) status of a canine mammal, wherein said primers are capable of amplifying all or part of the HSF4 locus, wherein the amplified region is less than 300 nucleotides in length, and comprises at least one HSF4 marker associated with the HC condition.
A method of HC therapy in a canine mammal affected by HC, which method comprises increasing the level of non-mutant HSF4 gene expression and/or HSF4 gene product activity in the mammal.
Dependencies are inferred from the claim text.