# US 2010/0168166 A1 · Method of Providing An Antihistaminic Effect in a Hepatically Impaired Patient

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- Number: US 2010/0168166 A1
- Document ID: US20100168166A1
- Status: Published application
- Kind: A1
- Application number: 12/496,153
- Filed: 2009-07-01
- Published: 2010-07-01
- Earliest claimed: 1992-05-11
- Inventors: James K. Woodward; Richard A. Okerholm; Mark G. Eller; Bruce E. McNutt
- Web page: https://patentgrep.com/patent/US20100168166A1

## CPC

- A61K 31/445: Non condensed piperidines, e.g. piperocaine
- A61P 11/06: Antiasthmatics
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective antihistaminic amount of a compound of the formula wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A and B is hydrogen or hydroxy with the proviso that at least one of A or B is hydrogen; or a pharmaceutically acceptable salt and individual isomers thereof.

## Claims

### Claim at position 1

1-7. (canceled)

### Claim 8

A method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective antihistaminic amount of (R)-4-[1-hydroxy-4-[4-hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-benzeneacetic acid, (S)-4-[1-hydroxy-4-[4-hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-benzeneacetic acid, or a pharmaceutically acceptable salt thereof.