# US 2010/0168111 A1 · Polymorphic form of 5 chloro n {[(5s) 2 oxo 3 [4 (3 oxomorpholin 4 yl)phenyl]oxa-zolidin 5 yl]-methyl}thiophene 2 carboxamide > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2010/0168111 A1 - Document ID: US20100168111A1 - Status: Published application - Kind: A1 - Application number: 12/347,176 - Filed: 2008-12-31 - Published: 2010-07-01 - Earliest claimed: 2008-12-31 - Assignees: Apotex Pharmachem Inc. - Inventors: Prabhudas Bodhuri; Gamini Weeratunga - Web page: https://patentgrep.com/patent/US20100168111A1 ## CPC - A61K 31/5377: not condensed and containing further heterocyclic rings, e.g. timolol - A61P 7/02: Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors - A61P 9/00: Drugs for disorders of the cardiovascular system - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - C07D 413/14: containing three or more hetero rings - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08) ## Abstract A polymorphic form of rivaroxaban, 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxa-zolidin-5-yl]-methyl}thiophene-2-carboxamide (termed form APO-A), processes for the preparation thereof, and compositions and formulations comprising form APO-A are provided. Also provided are compositions comprising a crystalline form of rivaroxaban and solvents selected from C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ## Claims ### Claim 1 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 39.12 degrees two-theta. ### Claim 2 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 3 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta. ### Claim 4 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 34.60 degrees two-theta. ### Claim 5 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 6 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta. ### Claim 7 (depends on 1) The polymorphic form of claim 1 wherein the X-ray diffraction pattern further comprises a peak at about 34.60 degrees two-theta. ### Claim 8 (depends on 1) The polymorphic form of claim 1 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 9 (depends on 1) The polymorphic form of claim 1 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta. ### Claim 10 (depends on 2) The polymorphic form of claim 2 wherein the X-ray diffraction pattern further comprises a peak at about 34.60 degrees two-theta. ### Claim 11 (depends on 2) The polymorphic form of claim 2 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 12 (depends on 2) The polymorphic form of claim 2 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta. ### Claim 13 (depends on 3) The polymorphic form of claim 3 wherein the X-ray diffraction pattern further comprises a peak at about 34.60 degrees two-theta. ### Claim 14 (depends on 3) The polymorphic form of claim 3 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 15 (depends on 3) The polymorphic form of claim 3 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta. ### Claim 16 (depends on 1) The polymorphic form of claim 1 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 17 (depends on 1) The polymorphic form of claim 1 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 18 (depends on 1) The polymorphic form of claim 1 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 19 (depends on 2) The polymorphic form of claim 2 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 20 (depends on 2) The polymorphic form of claim 2 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 21 (depends on 2) The polymorphic form of claim 2 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 22 (depends on 3) The polymorphic form of claim 3 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 23 (depends on 3) The polymorphic form of claim 3 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 24 (depends on 3) The polymorphic form of claim 3 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 25 (depends on 4) The polymorphic form of claim 4 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 26 (depends on 4) The polymorphic form of claim 4 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 27 (depends on 4) The polymorphic form of claim 4 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 28 (depends on 5) The polymorphic form of claim 5 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 29 (depends on 5) The polymorphic form of claim 5 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 30 (depends on 5) The polymorphic form of claim 5 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 31 (depends on 6) The polymorphic form of claim 6 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 32 (depends on 6) The polymorphic form of claim 6 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 33 (depends on 6) The polymorphic form of claim 6 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 34 (depends on 7) The polymorphic form of claim 7 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 35 (depends on 7) The polymorphic form of claim 7 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 36 (depends on 7) The polymorphic form of claim 7 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 37 (depends on 8) The polymorphic form of claim 8 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 38 (depends on 8) The polymorphic form of claim 8 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 39 (depends on 8) The polymorphic form of claim 8 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 40 (depends on 9) The polymorphic form of claim 9 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 41 (depends on 9) The polymorphic form of claim 9 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 42 (depends on 9) The polymorphic form of claim 9 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 43 (depends on 10) The polymorphic form of claim 10 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 44 (depends on 10) The polymorphic form of claim 10 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 45 (depends on 10) The polymorphic form of claim 10 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 46 (depends on 11) The polymorphic form of claim 11 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 47 (depends on 11) The polymorphic form of claim 11 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 48 (depends on 11) The polymorphic form of claim 11 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 49 (depends on 12) The polymorphic form of claim 12 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 50 (depends on 12) The polymorphic form of claim 12 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 51 (depends on 12) The polymorphic form of claim 12 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 52 (depends on 13) The polymorphic form of claim 13 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 53 (depends on 13) The polymorphic form of claim 13 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 54 (depends on 13) The polymorphic form of claim 13 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 55 (depends on 14) The polymorphic form of claim 14 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 56 (depends on 14) The polymorphic form of claim 14 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 57 (depends on 14) The polymorphic form of claim 14 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 58 (depends on 15) The polymorphic form of claim 15 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 59 (depends on 15) The polymorphic form of claim 15 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 60 (depends on 15) The polymorphic form of claim 15 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 61 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 39.12 degrees two-theta with a relative intensity of at least about 8.72%. ### Claim 62 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta plus or minus 0.2 degree two-theta with a relative intensity of at least about 8.72%. ### Claim 63 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta with a relative intensity of at least about 8.72%. ### Claim 64 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 34.60 degrees two-theta with a relative intensity of at least about 8.45%. ### Claim 65 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta with a relative intensity of at least about 8.45%. ### Claim 66 A polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta with a relative intensity of at least about 8.45%. ### Claim 67 (depends on 61) The polymorphic form of claim 61 wherein the X-ray diffraction pattern further comprises a peak at about 34.60 degrees two-theta with a relative intensity of at least about 8.45%. ### Claim 68 (depends on 61) The polymorphic form of claim 61 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta with a relative intensity of at least about 8.45%. ### Claim 69 (depends on 61) The polymorphic form of claim 61 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta with a relative intensity of at least about 8.45%. ### Claim 70 (depends on 62) The polymorphic form of claim 62 wherein the X-ray diffraction pattern further comprises a peak at about 34.60 degrees two-theta with a relative intensity of at least about 8.45%. ### Claim 71 (depends on 62) The polymorphic form of claim 62 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta with a relative intensity of at least about 8.45%. ### Claim 72 (depends on 62) The polymorphic form of claim 62 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta with a relative intensity of at least about 8.45%. ### Claim 73 (depends on 63) The polymorphic form of claim 63 wherein the X-ray diffraction pattern further comprises a peak at about 34.60 degrees two-theta with a relative intensity of at least about 8.45%. ### Claim 74 (depends on 63) The polymorphic form of claim 63 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta with a relative intensity of at least about 8.45%. ### Claim 75 (depends on 63) The polymorphic form of claim 63 wherein the X-ray diffraction pattern further comprises a peak at 34.60 degrees two-theta with a relative intensity of at least about 8.45%. ### Claim 76 (depends on 61) The polymorphic form of claim 61 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 77 (depends on 61) The polymorphic form of claim 61 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 78 (depends on 61) The polymorphic form of claim 61 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 79 (depends on 62) The polymorphic form of claim 62 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 80 (depends on 62) The polymorphic form of claim 62 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 81 (depends on 62) The polymorphic form of claim 62 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 82 (depends on 63) The polymorphic form of claim 63 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 83 (depends on 63) The polymorphic form of claim 63 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 84 (depends on 63) The polymorphic form of claim 63 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 85 (depends on 64) The polymorphic form of claim 64 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 86 (depends on 64) The polymorphic form of claim 64 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 87 (depends on 64) The polymorphic form of claim 64 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 88 (depends on 65) The polymorphic form of claim 65 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 89 (depends on 65) The polymorphic form of claim 65 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 90 (depends on 65) The polymorphic form of claim 65 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 91 (depends on 66) The polymorphic form of claim 66 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 92 (depends on 66) The polymorphic form of claim 66 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 93 (depends on 66) The polymorphic form of claim 66 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 94 (depends on 67) The polymorphic form of claim 67 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 95 (depends on 67) The polymorphic form of claim 67 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 96 (depends on 67) The polymorphic form of claim 67 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 97 (depends on 68) The polymorphic form of claim 68 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 98 (depends on 68) The polymorphic form of claim 68 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 99 (depends on 68) The polymorphic form of claim 68 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 100 (depends on 69) The polymorphic form of claim 69 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 101 (depends on 69) The polymorphic form of claim 69 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 102 (depends on 69) The polymorphic form of claim 69 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 103 (depends on 70) The polymorphic form of claim 70 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 104 (depends on 70) The polymorphic form of claim 70 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 105 (depends on 70) The polymorphic form of claim 70 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 106 (depends on 71) The polymorphic form of claim 71 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 107 (depends on 71) The polymorphic form of claim 71 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 108 (depends on 71) The polymorphic form of claim 71 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 109 (depends on 72) The polymorphic form of claim 72 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 110 (depends on 72) The polymorphic form of claim 72 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 111 (depends on 72) The polymorphic form of claim 72 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 112 (depends on 73) The polymorphic form of claim 73 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 113 (depends on 73) The polymorphic form of claim 73 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 114 (depends on 73) The polymorphic form of claim 73 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 115 (depends on 74) The polymorphic form of claim 74 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 116 (depends on 74) The polymorphic form of claim 74 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 117 (depends on 74) The polymorphic form of claim 74 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 118 (depends on 75) The polymorphic form of claim 75 wherein the X-ray diffraction pattern further comprises peaks at about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 119 (depends on 75) The polymorphic form of claim 75 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 120 (depends on 75) The polymorphic form of claim 75 wherein the X-ray diffraction pattern further comprises peaks at 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta, each peak having a relative intensity of at least about 14.62%, at least about 10.64%, at least about 7.42% and at least about 6.30%, respectively. ### Claim 121 (depends on 1) The polymorph of claim 1 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 122 (depends on 2) The polymorph of claim 2 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 123 (depends on 3) The polymorph of claim 3 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 124 (depends on 4) The polymorph of claim 4 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 125 (depends on 5) The polymorph of claim 5 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 126 (depends on 6) The polymorph of claim 6 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 127 (depends on 7) The polymorph of claim 7 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 128 (depends on 8) The polymorph of claim 8 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 129 (depends on 9) The polymorph of claim 9 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 130 (depends on 10) The polymorph of claim 10 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 131 (depends on 11) The polymorph of claim 11 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 132 (depends on 12) The polymorph of claim 12 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 133 (depends on 13) The polymorph of claim 13 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 134 (depends on 14) The polymorph of claim 14 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 135 (depends on 15) The polymorph of claim 15 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 136 (depends on 16) The polymorph of claim 16 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 137 (depends on 17) The polymorph of claim 17 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 138 (depends on 18) The polymorph of claim 18 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 139 (depends on 19) The polymorph of claim 19 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 140 (depends on 20) The polymorph of claim 20 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 141 (depends on 21) The polymorph of claim 21 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 142 (depends on 22) The polymorph of claim 22 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 143 (depends on 23) The polymorph of claim 23 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 144 (depends on 24) The polymorph of claim 24 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 145 (depends on 25) The polymorph of claim 25 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 146 (depends on 26) The polymorph of claim 26 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 147 (depends on 27) The polymorph of claim 27 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 148 (depends on 28) The polymorph of claim 28 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 149 (depends on 29) The polymorph of claim 29 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 150 (depends on 30) The polymorph of claim 30 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 151 (depends on 31) The polymorph of claim 31 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 152 (depends on 32) The polymorph of claim 32 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 153 (depends on 33) The polymorph of claim 33 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 154 (depends on 34) The polymorph of claim 34 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 155 (depends on 35) The polymorph of claim 35 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 156 (depends on 36) The polymorph of claim 36 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 157 (depends on 37) The polymorph of claim 37 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 158 (depends on 38) The polymorph of claim 38 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 159 (depends on 39) The polymorph of claim 39 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 160 (depends on 40) The polymorph of claim 40 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 161 (depends on 41) The polymorph of claim 41 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 162 (depends on 42) The polymorph of claim 42 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 163 (depends on 43) The polymorph of claim 43 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 164 (depends on 44) The polymorph of claim 44 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 165 (depends on 45) The polymorph of claim 45 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 166 (depends on 46) The polymorph of claim 46 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 167 (depends on 47) The polymorph of claim 47 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 168 (depends on 48) The polymorph of claim 48 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 169 (depends on 49) The polymorph of claim 49 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 170 (depends on 50) The polymorph of claim 50 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 171 (depends on 51) The polymorph of claim 51 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 172 (depends on 52) The polymorph of claim 52 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 173 (depends on 53) The polymorph of claim 53 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 174 (depends on 54) The polymorph of claim 54 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 175 (depends on 55) The polymorph of claim 55 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 176 (depends on 56) The polymorph of claim 56 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 177 (depends on 57) The polymorph of claim 57 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 178 (depends on 58) The polymorph of claim 58 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 179 (depends on 59) The polymorph of claim 59 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 180 (depends on 60) The polymorph of claim 60 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 181 (depends on 61) The polymorph of claim 61 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 182 (depends on 62) The polymorph of claim 62 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 183 (depends on 63) The polymorph of claim 63 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 184 (depends on 64) The polymorph of claim 64 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 185 (depends on 65) The polymorph of claim 65 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 186 (depends on 66) The polymorph of claim 66 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 187 (depends on 67) The polymorph of claim 67 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 188 (depends on 68) The polymorph of claim 68 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 189 (depends on 69) The polymorph of claim 69 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 190 (depends on 70) The polymorph of claim 70 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 191 (depends on 71) The polymorph of claim 71 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 192 (depends on 72) The polymorph of claim 72 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 193 (depends on 73) The polymorph of claim 73 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 194 (depends on 74) The polymorph of claim 74 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 195 (depends on 75) The polymorph of claim 75 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 196 (depends on 76) The polymorph of claim 76 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 197 (depends on 77) The polymorph of claim 77 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 198 (depends on 78) The polymorph of claim 78 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 199 (depends on 79) The polymorph of claim 79 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 200 (depends on 80) The polymorph of claim 80 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 201 (depends on 81) The polymorph of claim 81 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 202 (depends on 82) The polymorph of claim 82 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 203 (depends on 83) The polymorph of claim 83 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 204 (depends on 84) The polymorph of claim 84 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 205 (depends on 85) The polymorph of claim 85 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 206 (depends on 86) The polymorph of claim 86 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 207 (depends on 87) The polymorph of claim 87 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 208 (depends on 88) The polymorph of claim 88 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 209 (depends on 89) The polymorph of claim 89 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 210 (depends on 90) The polymorph of claim 90 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 211 (depends on 91) The polymorph of claim 91 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 212 (depends on 92) The polymorph of claim 92 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 213 (depends on 93) The polymorph of claim 93 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 214 (depends on 94) The polymorph of claim 94 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 215 (depends on 95) The polymorph of claim 95 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 216 (depends on 96) The polymorph of claim 96 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 217 (depends on 97) The polymorph of claim 97 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 218 (depends on 98) The polymorph of claim 98 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 219 (depends on 99) The polymorph of claim 99 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 220 (depends on 100) The polymorph of claim 100 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 221 (depends on 101) The polymorph of claim 101 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 222 (depends on 102) The polymorph of claim 102 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 223 (depends on 103) The polymorph of claim 103 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 224 (depends on 104) The polymorph of claim 104 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 225 (depends on 105) The polymorph of claim 105 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 226 (depends on 106) The polymorph of claim 106 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166+ C. and a peak maximum at about 183° C. ### Claim 227 (depends on 107) The polymorph of claim 107 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 228 (depends on 108) The polymorph of claim 108 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 229 (depends on 109) The polymorph of claim 109 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 230 (depends on 110) The polymorph of claim 110 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 231 (depends on 111) The polymorph of claim 111 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 232 (depends on 112) The polymorph of claim 112 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 233 (depends on 113) The polymorph of claim 113 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 234 (depends on 114) The polymorph of claim 114 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 235 (depends on 115) The polymorph of claim 115 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 236 (depends on 116) The polymorph of claim 116 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 237 (depends on 117) The polymorph of claim 117 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 238 (depends on 118) The polymorph of claim 118 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 239 (depends on 119) The polymorph of claim 119 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 240 (depends on 120) The polymorph of claim 120 further characterized by a DSC thermogram exhibiting a peak endotherm at an onset temperature of about 166° C. and a peak maximum at about 183° C. ### Claim 241 A process for the preparation of form APO-A comprising: a. combining a compound of formula (1): with an organic solvent or a mixture of solvents to form a mixture; b. heating the mixture; C. removing undissolved solid to form a solution; d. promoting crystal growth; and e. collecting crystals. ### Claim 242 (depends on 241) The process of claim 241 wherein crystals are collected by filtration. ### Claim 243 (depends on 241) The process of claim 241 wherein the starting compound of formula (1) is a polymorphic form other than form APO-A. ### Claim 244 (depends on 242) The process of claim 242 wherein the starting compound of formula (1) is a polymorphic form other than form APO-A. ### Claim 245 (depends on 241) The process of claim 241 wherein the starting compound of formula (1) is polymorphic form modification 1. ### Claim 246 (depends on 242) The process of claim 242 wherein the starting compound of formula (1) is polymorphic form modification 1. ### Claim 247 (depends on 241) The process of claim 241 wherein the starting compound of formula (1) is an amorphous form. ### Claim 248 (depends on 242) The process of claim 242 wherein the starting compound of formula (1) is an amorphous form. ### Claim 249 (depends on 241) The process of claim 241 wherein crystal growth is promoted by cooling the solution. ### Claim 250 (depends on 242) The process of claim 242 wherein crystal growth is promoted by cooling the solution. ### Claim 251 (depends on 243) The process of claim 243 wherein crystal growth is promoted by cooling the solution. ### Claim 252 (depends on 244) The process of claim 244 wherein crystal growth is promoted by cooling the solution. ### Claim 253 (depends on 245) The process of claim 245 wherein crystal growth is promoted by cooling the solution. ### Claim 254 (depends on 246) The process of claim 246 wherein crystal growth is promoted by cooling the solution. ### Claim 255 (depends on 247) The process of claim 247 wherein crystal growth is promoted by cooling the solution. ### Claim 256 (depends on 248) The process of claim 248 wherein crystal growth is promoted by cooling the solution. ### Claim 257 (depends on 241) The process of claim 241 wherein crystal growth is promoted by seeding the solution. ### Claim 258 (depends on 242) The process of claim 242 wherein crystal growth is promoted by seeding the solution. ### Claim 259 (depends on 243) The process of claim 243 wherein crystal growth is promoted by seeding the solution. ### Claim 260 (depends on 244) The process of claim 244 wherein crystal growth is promoted by seeding the solution. ### Claim 261 (depends on 245) The process of claim 245 wherein crystal growth is promoted by seeding the solution. ### Claim 262 (depends on 246) The process of claim 246 wherein crystal growth is promoted by seeding the solution. ### Claim 263 (depends on 247) The process of claim 247 wherein crystal growth is promoted by seeding the solution. ### Claim 264 (depends on 248) The process of claim 248 wherein crystal growth is promoted by seeding the solution. ### Claim 265 (depends on 241) The process of claim 241 wherein crystal growth is promoted by cooling and seeding the solution. ### Claim 266 (depends on 242) The process of claim 242 wherein crystal growth is promoted by cooling and seeding the solution. ### Claim 267 (depends on 243) The process of claim 243 wherein crystal growth is promoted by cooling and seeding the solution. ### Claim 268 (depends on 244) The process of claim 244 wherein crystal growth is promoted by cooling and seeding the solution. ### Claim 269 (depends on 245) The process of claim 245 wherein crystal growth is promoted by cooling and seeding the solution. ### Claim 270 (depends on 246) The process of claim 246 wherein crystal growth is promoted by cooling and seeding the solution. ### Claim 271 (depends on 247) The process of claim 247 wherein crystal growth is promoted by cooling and seeding the solution. ### Claim 272 (depends on 248) The process of claim 248 wherein crystal growth is promoted by cooling and seeding the solution. ### Claim 273 (depends on 241) The process of claim 241 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 274 (depends on 242) The process of claim 242 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 275 (depends on 243) The process of claim 243 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 276 (depends on 244) The process of claim 244 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 277 (depends on 245) The process of claim 245 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 278 (depends on 246) The process of claim 246 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 279 (depends on 247) The process of claim 247 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 280 (depends on 248) The process of claim 248 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 281 (depends on 249) The process of claim 249 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 282 (depends on 250) The process of claim 250 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 283 (depends on 251) The process of claim 251 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 284 (depends on 252) The process of claim 252 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 285 (depends on 253) The process of claim 253 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 286 (depends on 254) The process of claim 254 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 287 (depends on 255) The process of claim 255 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 288 (depends on 256) The process of claim 256 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 289 (depends on 257) The process of claim 257 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 290 (depends on 258) The process of claim 258 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 291 (depends on 259) The process of claim 259 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 292 (depends on 260) The process of claim 260 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 293 (depends on 261) The process of claim 261 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 294 (depends on 262) The process of claim 262 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 295 (depends on 263) The process of claim 263 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 296 (depends on 264) The process of claim 264 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 297 (depends on 265) The process of claim 265 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 298 (depends on 266) The process of claim 266 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 299 (depends on 267) The process of claim 267 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 300 (depends on 268) The process of claim 268 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 301 (depends on 269) The process of claim 269 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 302 (depends on 270) The process of claim 270 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 303 (depends on 271) The process of claim 271 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 304 (depends on 272) The process of claim 272 wherein the organic solvent comprises at least one selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 305 (depends on 241) The process of claim 241 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 306 (depends on 242) The process of claim 242 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 307 (depends on 243) The process of claim 243 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 308 (depends on 244) The process of claim 244 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 309 (depends on 245) The process of claim 245 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 310 (depends on 246) The process of claim 246 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 311 (depends on 247) The process of claim 247 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 312 (depends on 248) The process of claim 248 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 313 (depends on 249) The process of claim 249 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 314 (depends on 250) The process of claim 250 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 315 (depends on 251) The process of claim 251 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 316 (depends on 252) The process of claim 252 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 317 (depends on 253) The process of claim 253 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 318 (depends on 254) The process of claim 254 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 319 (depends on 255) The process of claim 255 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 320 (depends on 256) The process of claim 256 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 321 (depends on 257) The process of claim 257 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 322 (depends on 258) The process of claim 258 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 323 (depends on 259) The process of claim 259 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 324 (depends on 260) The process of claim 260 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 325 (depends on 261) The process of claim 261 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 326 (depends on 262) The process of claim 262 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 327 (depends on 263) The process of claim 263 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 328 (depends on 264) The process of claim 264 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 329 (depends on 265) The process of claim 265 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 330 (depends on 266) The process of claim 266 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 331 (depends on 267) The process of claim 267 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 332 (depends on 268) The process of claim 268 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 333 (depends on 269) The process of claim 269 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 334 (depends on 270) The process of claim 270 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 335 (depends on 271) The process of claim 271 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 336 (depends on 272) The process of claim 272 wherein the organic solvent comprises at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 337 (depends on 241) The process of claim 241 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 338 (depends on 242) The process of claim 242 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 339 (depends on 243) The process of claim 243 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 340 (depends on 244) The process of claim 244 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 341 (depends on 245) The process of claim 245 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 342 (depends on 246) The process of claim 246 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 343 (depends on 247) The process of claim 247 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 344 (depends on 248) The process of claim 248 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 345 (depends on 249) The process of claim 249 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 346 (depends on 250) The process of claim 250 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 347 (depends on 251) The process of claim 251 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 348 (depends on 252) The process of claim 252 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 349 (depends on 253) The process of claim 253 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 350 (depends on 254) The process of claim 254 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 351 (depends on 255) The process of claim 255 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 352 (depends on 256) The process of claim 256 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 353 (depends on 257) The process of claim 257 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 354 (depends on 258) The process of claim 258 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 355 (depends on 259) The process of claim 259 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 356 (depends on 260) The process of claim 260 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 357 (depends on 261) The process of claim 261 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 358 (depends on 262) The process of claim 262 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 359 (depends on 263) The process of claim 263 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 360 (depends on 264) The process of claim 264 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 361 (depends on 265) The process of claim 265 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 362 (depends on 266) The process of claim 266 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 363 (depends on 267) The process of claim 267 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 364 (depends on 268) The process of claim 268 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 365 (depends on 269) The process of claim 269 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 366 (depends on 270) The process of claim 270 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 367 (depends on 271) The process of claim 271 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 368 (depends on 272) The process of claim 272 wherein the organic solvent is selected from at least one of the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 369 (depends on 241) The process of claim 241 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 370 (depends on 242) The process of claim 242 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 371 (depends on 243) The process of claim 243 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 372 (depends on 244) The process of claim 244 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 373 (depends on 245) The process of claim 245 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 374 (depends on 246) The process of claim 246 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 375 (depends on 247) The process of claim 247 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 376 (depends on 248) The process of claim 248 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 377 (depends on 249) The process of claim 249 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 378 (depends on 250) The process of claim 250 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 379 (depends on 251) The process of claim 251 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 380 (depends on 252) The process of claim 252 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 381 (depends on 253) The process of claim 253 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 382 (depends on 254) The process of claim 254 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 383 (depends on 255) The process of claim 255 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 384 (depends on 256) The process of claim 256 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 385 (depends on 257) The process of claim 257 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 386 (depends on 258) The process of claim 258 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 387 (depends on 259) The process of claim 259 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 388 (depends on 260) The process of claim 260 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 389 (depends on 261) The process of claim 261 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 390 (depends on 262) The process of claim 262 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 391 (depends on 263) The process of claim 263 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 392 (depends on 264) The process of claim 264 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 393 (depends on 265) The process of claim 265 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 394 (depends on 266) The process of claim 266 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 395 (depends on 267) The process of claim 267 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 396 (depends on 268) The process of claim 268 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 397 (depends on 269) The process of claim 269 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 398 (depends on 270) The process of claim 270 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 399 (depends on 271) The process of claim 271 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 400 (depends on 272) The process of claim 272 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 401 (depends on 241) The process of claim 241 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 402 (depends on 242) The process of claim 242 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 403 (depends on 243) The process of claim 243 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 404 (depends on 244) The process of claim 244 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 405 (depends on 245) The process of claim 245 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 406 (depends on 246) The process of claim 246 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 407 (depends on 247) The process of claim 247 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 408 (depends on 248) The process of claim 248 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 409 (depends on 249) The process of claim 249 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 410 (depends on 250) The process of claim 250 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 411 (depends on 251) The process of claim 251 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 412 (depends on 252) The process of claim 252 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 413 (depends on 253) The process of claim 253 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 414 (depends on 254) The process of claim 254 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 415 (depends on 255) The process of claim 255 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 416 (depends on 256) The process of claim 256 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 417 (depends on 257) The process of claim 257 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 418 (depends on 258) The process of claim 258 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 419 (depends on 259) The process of claim 259 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 420 (depends on 260) The process of claim 260 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 421 (depends on 261) The process of claim 261 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 422 (depends on 262) The process of claim 262 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 423 (depends on 263) The process of claim 263 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 424 (depends on 264) The process of claim 264 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 425 (depends on 265) The process of claim 265 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 426 (depends on 266) The process of claim 266 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 427 (depends on 267) The process of claim 267 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 428 (depends on 268) The process of claim 268 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 429 (depends on 269) The process of claim 269 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 430 (depends on 270) The process of claim 270 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 431 (depends on 271) The process of claim 271 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 432 (depends on 272) The process of claim 272 wherein the organic solvent consists of methyl-isobutylketone. ### Claim 433 A product comprising form APO-A made by a process comprising: a. combining a compound of formula (1): with an organic solvent or a mixture of solvents to form a mixture; b. heating the mixture; C. removing undissolved solid to form a solution; d. promoting crystal growth; and e. collecting crystals. ### Claim 434 (depends on 433) The product comprising form APO-A of claim 433 wherein the starting compound of formula (1) is polymorphic form modification 1, the organic solvent comprises methyl-isobutylketone, crystal growth is promoted by cooling the solution, and crystals are collected by filtration. ### Claim 435 (depends on 433) The product comprising form APO-A of claim 433 wherein the starting compound of formula (1) is polymorphic form modification I, the organic solvent consists of methyl-isobutylketone, crystal growth is promoted by cooling the solution, and crystals are collected by filtration. ### Claim 436 A pharmaceutical formulation comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 39.12 degrees two-theta. ### Claim 437 A pharmaceutical formulation comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 438 A pharmaceutical formulation comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta. ### Claim 439 A pharmaceutical formulation comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 34.60 degrees two-theta. ### Claim 440 A pharmaceutical formulation comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 441 A pharmaceutical formulation comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta. ### Claim 442 (depends on 436) The pharmaceutical formulation of claim 436 wherein the X-ray diffraction pattern further comprises peaks at about 34.60 degrees two-theta, about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 443 (depends on 437) The pharmaceutical formulation of claim 437 wherein the X-ray diffraction pattern further comprises peaks at 34.60 degrees two-theta plus or minus 0.2 degree two-theta, 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 444 (depends on 438) The pharmaceutical formulation of claim 438 wherein the X-ray diffraction pattern further comprises peaks at 34.60 degrees two-theta, 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 445 (depends on 442) The pharmaceutical formulation of claim 442 wherein the peak at about 39.12 degrees two-theta has a relative intensity of at least about 8.72%, the peak at about 34.60 degrees two-theta has a relative intensity of at least about 8.45%, the peak at about 25.78 degrees two-theta has a relative intensity of at least about 14.62%, the peak at about 22.44 degrees two-theta has a relative intensity of at least about 10.64%, the peak at about 19.27 degrees two-theta has a relative intensity of at least about 7.42% and the peak at about 8.97 degrees two-theta has a relative intensity of at least about 6.30%. ### Claim 446 (depends on 443) The pharmaceutical formulation of claim 443 wherein the peak at 39.12 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 8.72%, the peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 8.45%, the peak at 25.78 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 14.62%, the peak at 22.44 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 10.64%, the peak at 19.27 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 7.42% and the peak at 8.97 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 6.30%. ### Claim 447 (depends on 444) The pharmaceutical formulation of claim 444 wherein the peak at 39.12 degrees two-theta has a relative intensity of at least about 8.72%, the peak at 34.60 degrees two-theta has a relative intensity of at least about 8.45%, the peak at 25.78 degrees two-theta has a relative intensity of at least about 14.62%, the peak at 22.44 degrees two-theta has a relative intensity of at least about 10.64%, the peak at 19.27 degrees two-theta has a relative intensity of at least about 7.42% and the peak at 8.97 degrees two-theta has a relative intensity of at least about 6.30%. ### Claim 448 (depends on 436) The pharmaceutical formulation of claim 436 further comprising another polymorphic form of rivaroxaban. ### Claim 449 (depends on 437) The pharmaceutical formulation of claim 437 further comprising another polymorphic form of rivaroxaban. ### Claim 450 (depends on 438) The pharmaceutical formulation of claim 438 further comprising another polymorphic form of rivaroxaban. ### Claim 451 (depends on 439) The pharmaceutical formulation of claim 439 further comprising another polymorphic form of rivaroxaban. ### Claim 452 (depends on 440) The pharmaceutical formulation of claim 440 further comprising another polymorphic form of rivaroxaban. ### Claim 453 (depends on 441) The pharmaceutical formulation of claim 441 further comprising another polymorphic form of rivaroxaban. ### Claim 454 (depends on 442) The pharmaceutical formulation of claim 442 further comprising another polymorphic form of rivaroxaban. ### Claim 455 (depends on 443) The pharmaceutical formulation of claim 443 further comprising another polymorphic form of rivaroxaban. ### Claim 456 (depends on 444) The pharmaceutical formulation of claim 444 further comprising another polymorphic form of rivaroxaban. ### Claim 457 (depends on 445) The pharmaceutical formulation of claim 445 further comprising another polymorphic form of rivaroxaban. ### Claim 458 (depends on 446) The pharmaceutical formulation of claim 446 further comprising another polymorphic form of rivaroxaban. ### Claim 459 (depends on 436) The pharmaceutical formulation of claim 436 further comprising an amorphous form of rivaroxaban. ### Claim 460 (depends on 437) The pharmaceutical formulation of claim 437 further comprising an amorphous form of rivaroxaban. ### Claim 461 (depends on 438) The pharmaceutical formulation of claim 438 further comprising an amorphous form of rivaroxaban. ### Claim 462 (depends on 439) The pharmaceutical formulation of claim 439 further comprising an amorphous form of rivaroxaban. ### Claim 463 (depends on 440) The pharmaceutical formulation of claim 440 further comprising an amorphous form of rivaroxaban. ### Claim 464 (depends on 441) The pharmaceutical formulation of claim 441 further comprising an amorphous form of rivaroxaban. ### Claim 465 (depends on 442) The pharmaceutical formulation of claim 442 further comprising an amorphous form of rivaroxaban. ### Claim 466 (depends on 443) The pharmaceutical formulation of claim 443 further comprising an amorphous form of rivaroxaban. ### Claim 467 (depends on 444) The pharmaceutical formulation of claim 444 further comprising an amorphous form of rivaroxaban. ### Claim 468 (depends on 445) The pharmaceutical formulation of claim 445 further comprising an amorphous form of rivaroxaban. ### Claim 469 (depends on 446) The pharmaceutical formulation of claim 446 further comprising an amorphous form of rivaroxaban. ### Claim 470 (depends on 436) The pharmaceutical formulation of claim 436 further comprising methyl-isobutylketone. ### Claim 471 (depends on 437) The pharmaceutical formulation of claim 437 further comprising methyl-isobutylketone. ### Claim 472 (depends on 438) The pharmaceutical formulation of claim 438 further comprising methyl-isobutylketone. ### Claim 473 (depends on 439) The pharmaceutical formulation of claim 439 further comprising methyl-isobutylketone. ### Claim 474 (depends on 440) The pharmaceutical formulation of claim 440 further comprising methyl-isobutylketone. ### Claim 475 (depends on 441) The pharmaceutical formulation of claim 441 further comprising methyl-isobutylketone. ### Claim 476 (depends on 442) The pharmaceutical formulation of claim 442 further comprising methyl-isobutylketone. ### Claim 477 (depends on 443) The pharmaceutical formulation of claim 443 further comprising methyl-isobutylketone. ### Claim 478 (depends on 444) The pharmaceutical formulation of claim 444 further comprising methyl-isobutylketone. ### Claim 479 (depends on 445) The pharmaceutical formulation of claim 445 further comprising methyl-isobutylketone. ### Claim 480 (depends on 446) The pharmaceutical formulation of claim 446 further comprising methyl-isobutylketone. ### Claim 481 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 39.12 degrees two-theta and another polymorphic form of rivaroxaban. ### Claim 482 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta plus or minus 0.2 degree two-theta and another polymorphic form of rivaroxaban. ### Claim 483 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta and another polymorphic form of rivaroxaban. ### Claim 484 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 34.60 degrees two-theta and another polymorphic form of rivaroxaban. ### Claim 485 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta and another polymorphic form of rivaroxaban. ### Claim 486 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta and another polymorphic form of rivaroxaban. ### Claim 487 (depends on 481) The composition of claim 481 wherein the X-ray diffraction pattern further comprises peaks at about 34.60 degrees two-theta, about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 488 (depends on 482) The composition of claim 482 wherein the X-ray diffraction pattern further comprises peaks at 34.60 degrees two-theta plus or minus 0.2 degree two-theta, 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 489 (depends on 483) The composition of claim 483 wherein the X-ray diffraction pattern further comprises peaks at 34.60 degrees two-theta, 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 490 (depends on 487) The composition of claim 487 wherein the peak at about 39.12 degrees two-theta has a relative intensity of at least about 8.72%, the peak at about 34.60 degrees two-theta has a relative intensity of at least about 8.45%, the peak at about 25.78 degrees two-theta has a relative intensity of at least about 14.62%, the peak at about 22.44 degrees two-theta has a relative intensity of at least about 10.64%, the peak at about 19.27 degrees two-theta has a relative intensity of at least about 7.42% and the peak at about 8.97 degrees two-theta has a relative intensity of at least about 6.30%. ### Claim 491 (depends on 488) The composition of claim 488 wherein the peak at 39.12 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 8.72%, the peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 8.45%, the peak at 25.78 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 14.62%, the peak at 22.44 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 10.64%, the peak at 19.27 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 7.42% and the peak at 8.97 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 6.30%. ### Claim 492 (depends on 489) The composition of claim 489 wherein the peak at 39.12 degrees two-theta has a relative intensity of at least about 8.72%, the peak at 34.60 degrees two-theta has a relative intensity of at least about 8.45%, the peak at 25.78 degrees two-theta has a relative intensity of at least about 14.62%, the peak at 22.44 degrees two-theta has a relative intensity of at least about 10.64%, the peak at 19.27 degrees two-theta has a relative intensity of at least about 7.42% and the peak at 8.97 degrees two-theta has a relative intensity of at least about 6.30%. ### Claim 493 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 39.12 degrees two-theta and an amorphous form of rivaroxaban. ### Claim 494 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta plus or minus 0.2 degree two-theta and an amorphous form of rivaroxaban. ### Claim 495 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta and an amorphous form of rivaroxaban. ### Claim 496 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 34.60 degrees two-theta and an amorphous form of rivaroxaban. ### Claim 497 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta and an amorphous form of rivaroxaban. ### Claim 498 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta and an amorphous form of rivaroxaban. ### Claim 499 (depends on 493) The composition of claim 493 wherein the X-ray diffraction pattern further comprises peaks at about 34.60 degrees two-theta, about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 500 (depends on 494) The composition of claim 494 wherein the X-ray diffraction pattern further comprises peaks at 34.60 degrees two-theta plus or minus 0.2 degree two-theta, 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 501 (depends on 495) The composition of claim 495 wherein the X-ray diffraction pattern further comprises peaks at 34.60 degrees two-theta, 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 502 (depends on 499) The composition of claim 499 wherein the peak at about 39.12 degrees two-theta has a relative intensity of at least about 8.72%, the peak at about 34.60 degrees two-theta has a relative intensity of at least about 8.45%, the peak at about 25.78 degrees two-theta has a relative intensity of at least about 14.62%, the peak at about 22.44 degrees two-theta has a relative intensity of at least about 10.64%, the peak at about 19.27 degrees two-theta has a relative intensity of at least about 7.42% and the peak at about 8.97 degrees two-theta has a relative intensity of at least about 6.30%. ### Claim 503 (depends on 500) The composition of claim 500 wherein the peak at 39.12 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 8.72%, the peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 8.45%, the peak at 25.78 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 14.62%, the peak at 22.44 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 10.64%, the peak at 19.27 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 7.42% and the peak at 8.97 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 6.30%. ### Claim 504 (depends on 501) The composition of claim 501 wherein the peak at 39.12 degrees two-theta has a relative intensity of at least about 8.72%, the peak at 34.60 degrees two-theta has a relative intensity of at least about 8.45%, the peak at 25.78 degrees two-theta has a relative intensity of at least about 14.62%, the peak at 22.44 degrees two-theta has a relative intensity of at least about 10.64%, the peak at 19.27 degrees two-theta has a relative intensity of at least about 7.42% and the peak at 8.97 degrees two-theta has a relative intensity of at least about 6.30%. ### Claim 505 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 39.12 degrees two-theta and methyl-isobutylketone. ### Claim 506 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta plus or minus 0.2 degree two-theta and methyl-isobutylketone. ### Claim 507 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 39.12 degrees two-theta and methyl-isobutylketone. ### Claim 508 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at about 34.60 degrees two-theta and methyl-isobutylketone. ### Claim 509 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta and methyl-isobutylketone. ### Claim 510 A composition comprising a polymorphic form of rivaroxaban characterized by an X-ray diffraction pattern comprising a peak at 34.60 degrees two-theta and methyl-isobutylketone. ### Claim 511 (depends on 505) The composition of claim 505 wherein the X-ray diffraction pattern further comprises peaks at about 34.60 degrees two-theta, about 25.78 degrees two-theta, about 22.44 degrees two-theta, about 19.27 degrees two-theta and about 8.97 degrees two-theta. ### Claim 512 (depends on 506) The composition of claim 506 wherein the X-ray diffraction pattern further comprises peaks at 34.60 degrees two-theta plus or minus 0.2 degree two-theta, 25.78 degrees two-theta plus or minus 0.2 degree two-theta, 22.44 degrees two-theta plus or minus 0.2 degree two-theta, 19.27 degrees two-theta plus or minus 0.2 degree two-theta and 8.97 degrees two-theta plus or minus 0.2 degree two-theta. ### Claim 513 (depends on 507) The composition of claim 507 wherein the X-ray diffraction pattern further comprises peaks at 34.60 degrees two-theta, 25.78 degrees two-theta, 22.44 degrees two-theta, 19.27 degrees two-theta and 8.97 degrees two-theta. ### Claim 514 (depends on 511) The composition of claim 511 wherein the peak at about 39.12 degrees two-theta has a relative intensity of at least about 8.72%, the peak at about 34.60 degrees two-theta has a relative intensity of at least about 8.45%, the peak at about 25.78 degrees two-theta has a relative intensity of at least about 14.62%, the peak at about 22.44 degrees two-theta has a relative intensity of at least about 10.64%, the peak at about 19.27 degrees two-theta has a relative intensity of at least about 7.42% and the peak at about 8.97 degrees two-theta has a relative intensity of at least about 6.30%. ### Claim 515 (depends on 512) The composition of claim 512 wherein the peak at 39.12 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 8.72%, the peak at 34.60 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 8.45%, the peak at 25.78 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 14.62%, the peak at 22.44 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 10.64%, the peak at 19.27 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 7.42% and the peak at 8.97 degrees two-theta plus or minus 0.2 degree two-theta has a relative intensity of at least about 6.30%. ### Claim 516 (depends on 513) The composition of claim 513 wherein the peak at 39.12 degrees two-theta has a relative intensity of at least about 8.72%, the peak at 34.60 degrees two-theta has a relative intensity of at least about 8.45%, the peak at 25.78 degrees two-theta has a relative intensity of at least about 14.62%, the peak at 22.44 degrees two-theta has a relative intensity of at least about 10.64%, the peak at 19.27 degrees two-theta has a relative intensity of at least about 7.42% and the peak at 8.97 degrees two-theta has a relative intensity of at least about 6.30%. ### Claim 517 A composition comprising a crystalline form of rivaroxaban and an organic solvent selected from the group consisting of: C3 to C6 ketones, C3 to C4 amides and mixtures thereof. ### Claim 518 (depends on 517) The composition of claim 517 wherein the organic solvent is at least one selected from the group consisting of: 2-butanone, 3-pentanone, methyl-isobutylketone and cyclohexanone. ### Claim 519 (depends on 517) The composition of claim 517 wherein the organic solvent is at least one selected from the group consisting of: dimethylformamide and dimethylacetamide. ### Claim 520 (depends on 517) The composition of claim 517 wherein the organic solvent comprises methyl-isobutylketone. ### Claim 521 (depends on 517) The composition of claim 517 wherein the organic solvent is methyl-isobutylketone.