# US 2010/0168048 A1 · Method of Stabilizing S-Adenosyl-L-Methionine and Stabilized Composition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2010/0168048 A1 - Document ID: US20100168048A1 - Status: Published application - Kind: A1 - Application number: 12/161,030 - Filed: 2007-01-16 - Published: 2010-07-01 - Earliest claimed: 2006-01-17 - Assignees: Mitsubishi Gas Chemical Company, Inc. - Inventors: Kentarou Takano; Shinyo Gayama - Web page: https://patentgrep.com/patent/US20100168048A1 ## CPC - A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones - A61K 9/19: lyophilised {, i.e. freeze-dried, solutions or dispersions (lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00)} - A61K 31/7076: containing purines, e.g. adenosine, adenylic acid - A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics - A61P 19/02: for joint disorders, e.g. arthritis, arthrosis - A61P 25/24: Antidepressants - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - C07H 19/167: with ribosyl as the saccharide radical - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13) ## Abstract Provided are a process for producing a S-adenosyl-L-methionine-containing composition which is very excellent in a stability by adding at least ascorbic acids or salts thereof to a composition liquid containing S-adenosyl-L-methionine and then drying the above composition liquid or separating and drying a crystallized deposit obtained from the above composition liquid, a S-adenosyl-L-methionine-containing composition obtained by the above production process and a molding obtained from the above composition. ## Claims ### Claim 1 A production process for a S-adenosyl-L-methionine-containing composition, comprising adding at least ascorbic acids or salts thereof to a composition liquid containing S-adenosyl-L-methionine and then drying the above composition liquid or separating and drying a crystallized deposit obtained from the above composition liquid. ### Claim 2 (depends on 1) The production process for a S-adenosyl-L-methionine-containing composition as described in claim 1, wherein sulfuric acid or a salt thereof and the ascorbic acids or the salts thereof are added to the composition liquid containing S-adenosyl-L-methionine, and then the above composition liquid is dried or a crystallized deposit obtained from the above composition liquid is separated and dried. ### Claim 3 (depends on 1) The production process for a S-adenosyl-L-methionine-containing composition as described in claim 1, wherein p-toluenesulfonic acid or a salt thereof and the ascorbic acids or the salts thereof are added to the composition liquid containing S-adenosyl-L-methionine, and then the above composition liquid is dried or a crystallized deposit obtained from the above composition liquid is separated and dried. ### Claim 4 (depends on 1) The production process for a S-adenosyl-L-methionine-containing composition as described in claim 1, wherein sulfuric acid or a salt thereof, p-toluenesulfonic acid or a salt thereof and the ascorbic acids or the salts thereof are added to the composition liquid containing S-adenosyl-L-methionine, and then the above composition liquid is dried or a crystallized deposit obtained from the above composition liquid is separated and dried. ### Claim 5 (depends on 2) The production process for a S-adenosyl-L-methionine-containing composition as described in claim 2, wherein an amount ratio of sulfuric acid or the salt thereof to S-adenosyl-L-methionine contained in the S-adenosyl-L-methionine-containing composition obtained falls in a range of 0.1 to 3 time mole. ### Claim 6 (depends on 3) The production process for a S-adenosyl-L-methionine-containing composition as described in claim 3, wherein an amount ratio of p-toluenesulfonic acid or the salt thereof to S-adenosyl-L-methionine contained in the S-adenosyl-L-methionine-containing composition obtained falls in a range of 0.1 to 2 time mole. ### Claim 7 (depends on 1) The production process for a S-adenosyl-L-methionine-containing composition as described in claim 1, wherein an amount ratio of the ascorbic acids or the salts thereof to S-adenosyl-L-methionine contained in the S-adenosyl-L-methionine-containing composition obtained falls in a range of 0.1 to 2 time mole. ### Claim 8 (depends on 1) The production process for a S-adenosyl-L-methionine-containing composition as described in claim 1, wherein the ascorbic acids are ascorbic acid or ascorbic acid derivatives. ### Claim 9 (depends on 8) The production process for a S-adenosyl-L-methionine-containing composition as described in claim 8, wherein the ascorbic acid derivative is 2-glucoside ascorbate, phosphoric acid ascorbate, palmitic acid ascorbate or stearic acid ascorbate. ### Claim 10 (depends on 1) A S-adenosyl-L-methionine-containing composition obtained by the production process as described in claim 1. ### Claim 11 (depends on 10) A molding obtained from the S-adenosyl-L-methionine-containing composition as described in claim 10. ### Claim 12 (depends on 4) The production process for a S-adenosyl-L-methionine-containing composition as described in claim 4, wherein an amount ratio of sulfuric acid or the salt thereof to S-adenosyl-L-methionine contained in the S-adenosyl-L-methionine-containing composition obtained falls in a range of 0.1 to 3 time mole. ### Claim 13 (depends on 4) The production process for a S-adenosyl-L-methionine-containing composition as described in claim 4, wherein an amount ratio of p-toluenesulfonic acid or the salt thereof to S-adenosyl-L-methionine contained in the S-adenosyl-L-methionine-containing composition obtained falls in a range of 0.1 to 2 time mole.