# US 2010/0168044 A1 · Superparamagnetic nanoparticle encapsulated with stimuli responsive polymer for drug delivery > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2010/0168044 A1 - Document ID: US20100168044A1 - Status: Published application - Kind: A1 - Application number: 12/344,404 - Filed: 2008-12-26 - Published: 2010-07-01 - Earliest claimed: 2008-12-26 - Inventors: Devesh Kumar Misra - Web page: https://patentgrep.com/patent/US20100168044A1 ## CPC - A61K 31/519: ortho- or peri-condensed with heterocyclic rings - A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} - A61K 41/0052: {Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy} - A61K 47/6923: {the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract The current invention is a novel superparamagnetic site-targeting nanoparticle comprising superparamagnetic nanoparticles encapsulated with a smart polymer. The superparamagnetic site-targeting nanoparticle comprises a functionalized superparamagnetic core that is conjugated with a therapeutic agent and then encapsulated with a smart polymer. The smart polymer can be any polymer that exhibits a reversible conformational or physio-chemical change in response to an external stimulus or stimuli. ## Claims ### Claim 1 A superparamagnetic nanoparticle comprising: (a) a core having responsivity to a magnetic field, wherein said core comprises a surface; (b) a therapeutic agent conjugated to said surface of said core; and (c) a stimuli-responsive polymer encapsulating said core and said therapeutic agent. ### Claim 2 (depends on 1) The superparamagnetic nanoparticle in claim 1, wherein said core comprises Fe3O4. ### Claim 3 (depends on 2) The superparamagnetic nanoparticle in claim 2, wherein said surface of said core is functionalized with —NHNH2. ### Claim 4 (depends on 1) The superparamagnetic nanoparticle in claim 1, wherein said stimuli-responsive polymer comprises a biodegradable polymer. ### Claim 5 (depends on 3) The superparamagnetic nanoparticle in claim 3, wherein said stimuli-responsive polymer comprises a biodegradable polymer. ### Claim 6 (depends on 1) The superparamagnetic nanoparticle in claim 1, wherein said therapeutic agent comprises doxorubicin. ### Claim 7 (depends on 5) The superparamagnetic nanoparticle in claim 5, wherein said stimuli-responsive polymer comprises dextran-g-poly(NIPAAm-co-DMAAm) conjugated with folic acid. ### Claim 8 (depends on 5) The superparamagnetic nanoparticle in claim 5, wherein the stimuli-responsive polymer comprises chitosan-g-poly(NIPAAM-co-DMAAm). ### Claim 9 (depends on 8) The superparamagnetic nanoparticle in claim 8, wherein folic acid is conjugated with said chitosan-g-poly(NIPAAM-co-DMAAm). ### Claim 10 A method for making superparamagnetic nanoparticles, comprising the steps: (a) making a nanoparticle core having responsivity to a magnetic field, said nanoparticle comprising a surface; (b) functionalizing said surface of said nanoparticle core; (c) conjugating a therapeutic agent to said surface of said functionalized nanoparticle core; and (d) encapsulating said conjugated therapeutic agent and said nanoparticle core with a stimuli-responsive polymer. ### Claim 11 (depends on 10) The method for making a superparamagnetic nanoparticle in claim 10, wherein said therapeutic agent comprises doxorubicin. ### Claim 12 (depends on 10) The method for making a superparamagnetic nanoparticle in claim 10, wherein said stimuli-responsive polymer comprises a biodegradable polymer. ### Claim 13 (depends on 12) The method for making a superparamagnetic nanoparticle in claim 12, wherein said stimuli-responsive polymer comprises dextran-g-poly(NIPAAm-co-DMAAm) conjugated with folic acid. ### Claim 14 (depends on 12) The method for making a superparamagnetic nanoparticle in claim 12, wherein said stimuli-responsive polymer comprises chitosan-g-poly(NIPAAM-co-DMAAm). ### Claim 15 (depends on 14) The method for making a superparamagnetic nanoparticle in claim 14, wherein folic acid is conjugated with said chitosan-g-poly(NIPAAM-co-DMAAm). ### Claim 16 A method for making a superparamagnetic nanoparticle encapsulated with a stimuli-responsive polymer, comprising the steps: (a) making a nanoparticle core having responsivity to a magnetic field, said nanoparticle comprising a surface; (b) functionalizing said surface of said nanoparticle core with a —NHNH2 functional group; (c) conjugating a therapeutic agent to said surface of said functionalized nanoparticle core; and (d) encapsulating said conjugated therapeutic agent and said functionalized nanoparticle core with a stimuli-responsive polymer. ### Claim 17 (depends on 16) The method for making a superparamagnetic nanoparticle in claim 16, wherein said therapeutic agent comprises doxorubicin. ### Claim 18 (depends on 16) The method for making a superparamagnetic nanoparticle in claim 16, wherein said stimuli-responsive polymer comprises a biodegradable polymer. ### Claim 19 (depends on 18) The method for making a superparamagnetic nanoparticle in claim 18, wherein said stimuli-responsive polymer comprises dextran-g-poly(NIPAAm-co-DMAAm) conjugated with folic acid. ### Claim 20 (depends on 18) The method for making a superparamagnetic nanoparticle in claim 18, wherein said stimuli-responsive polymer comprises chitosan-g-poly(NIPAAM-co-DMAAm).