# US 2010/0168017 A1 · Functional serum protein product for use in infant food and therapeutic compositions and methods for the preparation thereof

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- Number: US 2010/0168017 A1
- Document ID: US20100168017A1
- Status: Published application
- Kind: A1
- Application number: 12/595,042
- Filed: 2008-04-16
- Published: 2010-07-01
- Earliest claimed: 2007-04-16
- Assignees: Friesland Brands B.V.
- Inventors: Cornelis GLAS
- Web page: https://patentgrep.com/patent/US20100168017A1

## CPC

- A23J 1/20: from milk, e.g. casein (curds or cheese A23C); from whey
- A23C 9/1422: {by ultrafiltration, microfiltration or diafiltration of milk, e.g. for separating protein and lactose; Treatment of the UF permeate}
- A23L 33/19: Dairy proteins
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 35/20: Milk; Whey; Colostrum
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/14: Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23J: PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23C: DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF (preservation thereof A23B11/00)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The invention relates to a serum protein product, suitable as an ingredient for foods and therapeutic compositions, in particular infant and baby foods. The invention also provides a method for the preparation of the serum protein product, based on micro filtration of milk. The invention provides a method for the preparation of a serum protein product, comprising the preparation of a permeate through micro filtration of cow's milk at a temperature of between 10 and 20° C. utilizing a membrane having a pore size of between 0.3 and 0.5 μm.

## Claims

### Claim 1

A method for the preparation of a serum protein product, comprising microfiltering milk from a ruminant with a microfiltration membrane having a pore size of between 0.3 and 0.5 μm, at a temperature of between 10 and 20° C. to obtain a permeate.

### Claim 2 (depends on 1)

A method according to claim 1, wherein the temperature is 10 to 15° C.

### Claim 3 (depends on 1)

A method according to claim 1, wherein the transmembrane pressure during said microfiltering is a maximum of 2.5 bar.

### Claim 4 (depends on 1)

A method according to claim 1, wherein the microfiltration membrane is spiral-wound.

### Claim 5 (depends on 1)

A method according to claim 1, wherein the pore size of the microfiltration membrane is approximately 0.45 μm.

### Claim 6 (depends on 1)

A method according to claim 1, which further comprises treating the permeate with one or more of the following processes: ultrafiltration, nanofiltration, ion exchange, electrodialysis, reverse osmosis, desalination, evaporation and spray-drying.

### Claim 7 (depends on 1)

A serum protein product obtainable according to the method of claim 1.

### Claim 8 (depends on 7)

A serum protein product according to claim 7, containing at least 60% of serum protein and at most 40% of casein, and wherein the casein fraction comprises more than 75% of beta casein.

### Claim 9 (depends on 8)

A serum protein product according to claim 8, containing at least 65% of serum protein and at most 35% of casein.

### Claim 10 (depends on 7)

A serum protein product according to claim 7, containing at least 12% of casein.

### Claim 11 (depends on 7)

A serum protein product according to claim 7, containing 6 to 11 grams of proline per 100 g of protein.

### Claim 12 (depends on 7)

A serum protein product according to claim 7, wherein the proline is substantially included in intact proteins.

### Claim 13 (depends on 7)

A serum protein product according to claim 7, containing more than 4.7 grams of threonine per 100 g of protein, wherein the threonine is substantially included in intact proteins.

### Claim 14 (depends on 7)

A method for the preparation of food or therapeutic composition, comprising mixing of the serum protein product of claim 7 with at least one additional protein, or lipid or carbohydrate source, optionally supplemented with minerals, oligo components and other ingredients.

### Claim 15 (depends on 14)

A method according to claim 14 wherein the food is a baby or infant food, having a serum protein to casein ratio of approximately 60:40 based on weight.

### Claim 16 (depends on 14)

A method according to claim 14, wherein, said additional protein source is, skim milk, caseinate, acid casein or milk protein concentrate.

### Claim 17 (depends on 14)

A food or therapeutic composition obtainable according to the method of claim 14.

### Claim 18 (depends on 17)

A method to promote the maturation of the intestinal wall and/or a proper closure of the tight junctions which comprises administering to a subject the food or therapeutic composition of claim 17.

### Claim 19 (depends on 11)

A method to stimulate the mucus formation of the intestinal wall and/or promoting the colonization resistance of the intestinal flora which comprises administering to a subject the food or therapeutic composition of claim 11.