# US 2010/0167360 A1 · Process for heterogeneously catalysed preparation of carboxylic acid derivatives > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2010/0167360 A1 - Document ID: US20100167360A1 - Status: Published application - Kind: A1 - Application number: 12/354,256 - Filed: 2009-01-15 - Published: 2010-07-01 - Earliest claimed: 2008-01-16 - Assignees: Evonik Degussa GmbH - Inventors: Oliver Thum; Lutz Hilterhaus; Andreas Liese - Web page: https://patentgrep.com/patent/US20100167360A1 ## CPC - C12P 7/62: Carboxylic acid esters - C12M 21/18: {Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes} - C12M 25/16: {Particles; Beads; Granular material; Encapsulation (chemical or physical processes conducted in the presence of fluids and solid particles B01J8/00)} - C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)} - C12M: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; {APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS} ## Abstract Process for heterogeneously catalysed preparation of carboxylic acid derivatives using a reactor system comprising at least one reservoir vessel V, feed lines, at least one pump and a reaction vessel R, characterized in that a permanent gas flow through the reaction vessel R is applied through a gas feed line, and in which a reaction chamber in which the heterogeneous catalyst is not introduced in tightly packed form is delimited by at least two filters such that both the mass flow and the gas flow are passed through the reaction chamber. ## Claims ### Claim 1 Process for heterogeneously catalysed preparation of carboxylic acid derivatives using a reactor system comprising at least one reservoir vessel V, feed lines, at least one pump and a reaction vessel R, characterized in that a permanent gas flow through the reaction vessel R is applied through a gas feed line, and in which a reaction chamber in which the heterogeneous catalyst is not introduced in tightly packed form is delimited by at least two filters such that both the mass flow and the gas flow are passed through the reaction chamber. ### Claim 2 (depends on 1) Process according to claim 1, characterized in that the catalyst used is at least one enzyme, or microorganisms comprising at least one enzyme. ### Claim 3 (depends on 2) Process according to claim 2, characterized in that the enzymatic system is present in heterogeneously supported form on a solid. ### Claim 4 (depends on 3) Process according to claim 3, characterized in that the enzymatic catalyst is fixed covalently or noncovalently in particulate form on a support material. ### Claim 5 (depends on 3) Process according to claim 3, characterized in that the solid consists of a polymer based on polyacrylate, polymethacrylate, polyvinylstyrene, styrene-divinylbenzene copolymers, polypropylene, polyethylene, polyethylene terephthalate, or polytetrafluoroethylene or copolymers of these compounds or oxidic and/or ceramic supports. ### Claim 6 (depends on 3) Process according to claim 3, characterized in that the solid consists of an acidic or basic ion exchange resin. ### Claim 7 (depends on 3) Process according to claim 3, characterized in that the oxidic and/or ceramic support consists of Celite, zeolites, silica or controlled-pore glass. ### Claim 8 (depends on 3) Process according to any one of claim 3, characterized in that the support material has a mean particle size of greater than 0.5 μm. ### Claim 9 (depends on 1) Process according to claim 1, characterized in that the heterogeneous catalyst system is reused. ### Claim 10 (depends on 1) Process according to claim 1, characterized in that vacuum is applied at the reservoir vessel V. ### Claim 11 (depends on 1) Process according to claim 1, characterized in that the gas used is air, lean air, oxygen, nitrogen, noble gases or carbon dioxide, preferably air or nitrogen. ### Claim 12 (depends on 1) Process according to claim 1, characterized in that the reaction is performed at a temperature of 20° C. to 100° C. ### Claim 13 (depends on 4) Process according to claim 4, characterized in that the solid consists of a polymer based on polyacrylate, polymethacrylate, polyvinylstyrene, styrene-divinylbenzene copolymers, polypropylene, polyethylene, polyethylene terephthalate, or polytetrafluoroethylene or copolymers of these compounds or oxidic and/or ceramic supports. ### Claim 14 (depends on 13) Process according to claim 13, characterized in that the solid consists of an acidic or basic ion exchange resin. ### Claim 15 (depends on 14) Process according to claim 14, characterized in that the oxidic and/or ceramic support consists of Celite, zeolites, silica or controlled-pore glass. ### Claim 16 (depends on 15) Process according to claim 15, characterized in that the support material has a mean particle size of greater than 0.5 μm. ### Claim 17 (depends on 16) Process according to claim 16, characterized in that the heterogeneous catalyst system is reused. ### Claim 18 (depends on 17) Process according to claim 17, characterized in that vacuum is applied at the reservoir vessel V. ### Claim 19 (depends on 18) Process according to claim 18, characterized in that the gas used is air, lean air, oxygen, nitrogen, noble gases or carbon dioxide, preferably air or nitrogen. ### Claim 20 (depends on 19) Process according to claim 19, characterized in that the reaction is performed at a temperature of 20° C. to 100° C.