# US 2010/0166892 A1 · Herbal composition phy906 and its use in chemotherapy

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- Number: US 2010/0166892 A1
- Document ID: US20100166892A1
- Status: Published application
- Kind: A1
- Application number: 12/527,302
- Filed: 2008-02-14
- Published: 2010-07-01
- Earliest claimed: 2007-02-15
- Assignees: Yale University; Phytoceutica, Inc.
- Inventors: Shwu-Huey Liu; Zaoli Jiang; Yung-Chi Cheng
- Web page: https://patentgrep.com/patent/US20100166892A1

## CPC

- A61K 36/725: Ziziphus, e.g. jujube
- A61K 31/4412: having oxo groups directly attached to the heterocyclic ring
- A61K 31/7068: having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K 36/484: Glycyrrhiza (licorice)
- A61K 36/539: Scutellaria (skullcap)
- A61K 36/65: Paeoniaceae (Peony family), e.g. Chinese peony
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

## Claims

### Claim 1

A composition comprising:
i) a pharmaceutically acceptable carrier;
ii) an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus, and Paeonia; and
iii) one or more cancer chemotherapeutic compounds.

### Claim 2 (depends on 1)

The composition of claim 1 wherein the plant species comprises Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba, and Paeonia lactiflora.

### Claim 3

(canceled)

### Claim 4 (depends on 1)

The composition of claim 1 wherein the cancer chemotherapeutic compound is selected from the group consisting of capecitabine and sorafenib.

### Claim 5

A method of increasing the therapeutic index or enhancing therapeutic effectiveness of a cancer therapeutic compound for the treatment of cancer comprising administering to a mammal in need thereof, a therapeutically effective amount of a composition comprising a pharmaceutically acceptable carrier, and an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus, and Paeonia.

### Claim 6

A method of treating cancer in a mammal in need thereof comprising administering to the mammal a therapeutically effective amount of a composition comprising:
i) a pharmaceutically acceptable carrier;
ii) an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus, and Paeonia; and
iii) a chemotherapeutic formulation comprising a cancer chemotherapeutic compound.

### Claim 7

A method of relieving side effects of a cancer chemotherapeutic compound in a mammal comprising administering a composition comprising:
i) a pharmaceutically acceptable carrier;
ii) an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus, and Paeonia; and
iii) a chemotherapeutic formulation comprising the cancer chemotherapeutic compound.

### Claim at position 8

8-10. (canceled)

### Claim 11

A method inhibiting the growth of tumors comprising administering a composition comprising:
iv) a pharmaceutically acceptable carrier;
v) an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus and Paeonia; and
vi) a chemotherapeutic formulation comprising a cancer chemotherapeutic compound.

### Claim 12 (depends on 11)

The method of claim 11, wherein the tumors are present in a mammal or in vitro cells.

### Claim at position 11

13-15. (canceled)

### Claim 16 (depends on 5, 6, 7, 8)

The method of claim 5, 6, 7, 8, or 11, wherein the cancer chemotherapeutic compound is selected from the group consisting of capecitabine and sorafenib.

### Claim 17 (depends on 5, 6)

The method of claim 5 or 6, wherein the cancer is a gastrointestinal cancer.